参芪二至汤加减联合西药治疗气阴两虚型IgA肾病临床观察  

Clinical Observation of Shenqi Erzhi Tang Combined with Western Medicine for IgA Nephropathy of Qi-yin Deficiency Type

作　　者：李亦聪[1] 李轶群[1] 钟韵畅 陈翠萍[1] 钟启腾[1] LI Yicong;LI Yiqun;ZHONG Yunchang;CHEN Cuiping;ZHONG Qiteng

机构地区：[1]惠州市中心人民医院中医科,广东惠州516001

出　　处：《新中医》2018年第3期87-90,共4页New Chinese Medicine

基　　金：惠州市科技计划项目(2015Y044)

摘　　要：目的:观察参芪二至汤加减联合西药治疗对气阴两虚型Ig A肾病的临床疗效。方法:将60例气阴两虚型IgA肾病患者随机分为治疗组和对照组各30例。对照组予常规西药治疗,治疗组在对照组治疗基础上予参芪二至汤加减。观察患者治疗前后24 h尿蛋白定量、血肌酐(SCr)、尿红细胞计数及中医证候积分的变化,评估治疗效果。结果:治疗1月,2组SCr水平及对照组尿蛋白定量、尿红细胞计数与治疗前比较,差异均无统计学意义(P>0.05);治疗组尿蛋白定量及尿红细胞计数均较治疗前降低(P<0.05),且均低于同期对照组(P<0.05)。治疗2月,2组尿蛋白定量、尿红细胞计数及治疗组SCr水平均较治疗前降低(P<0.05);治疗组尿蛋白定量及尿红细胞计数均低于对照组(P<0.05);2组SCr水平比较,差异无统计学意义(P>0.05)。治疗1月及2月,2组中医证候积分均较治疗前降低(P<0.05);治疗组的中医证候积分均低于同期对照组(P<0.05)。治疗组总有效率93.3%,对照组总有效率66.7%,2组比较,差异有统计学意义(P<0.01)。结论:参芪二至汤加减联合西药治疗气阴两虚型Ig A肾病疗效显著,与使用常规西药治疗比较,可有效地减少患者24 h尿蛋白、尿红细胞,降低SCr水平,从而有效改善临床症状,延缓病情进展。Objective： To observe the clinical effect of Shenqi Erzhi tang combined with western medicine for IgA nephropathy（IgAN） of qi-yin deficiency type. Methods：Divided 60 cases of patients with IgAN of qi-yin deficiency type into the treatment group and the control group randomly,30 cases in each group. The control group was given routine western medicine for treatment,while the treatment group was additionally given modified Shenqi Erzhi tang for treatment. Observed quantitative urinary protein in 24 hours,serum creatinine（SCr）,urine red blood cell count,and the changes of Chinese medicine syndrome scores of patients and evaluated the clinical effect. Results：After one month of treatment,compared the levels of SCr in two groups and the quantitative urinary protein in 24 hours and urine red blood cell count in the control group with those before treatment,there were no significant differences being found（P〈0.05）;the quantitative urinary protein in 24 hours and urine red blood cell count in the treatment group were decreased when compared with those before treatment and were lower than those in the control group at the same period（P〈0.05）. After two months of treatment,the quantitative urinary protein in 24 hours,urine red blood cell count,and levels of SCr in both groups were all decreased when compared with those before treatment;the quantitative urinary protein in 24 hours and urine red blood cell count in the treatment group were lower than those in the control group（P〈0.05）. There was no significant difference being found in the comparison of levels of SCr between two groups（P〉0.05）. At the end of 1 ^st and 2 ^nd month of treatment,Chinese medicine syndrome scores of two groups were all decreased when compared with those before treatment（P〈0.05）;Chinese medicine syndrome scores in the treatment group were lower than those in the control group at the same period（P〈0.05）. The total effective rate was93.3% in the treatment group and 66.7% in the control group,differen

关 键 词：IGA肾病 气阴两虚 中西医结合疗法 参芪二至汤 24 h尿蛋白定量 血肌酐(SCr) 尿红细胞计数 

分 类 号：R692[医药卫生—泌尿科学]