加味茵陈蒿汤联合顺铂腔内灌注治疗肝癌腹水临床观察  

Clinical Observation of Modified Yinchenhao Tang Combined with Cisplatin Intraperitoneal Perfusion for Ascites Hepatoma

作　　者：宋振民 宋会群 宋沛沛 SONG Zhenmin;SONG Huiqun;SONG Peipei

机构地区：[1]开封市中医院,河南开封475000 [2]开封市祥符区第二人民医院,河南开封475000 [3]开封市第二人民医院,河南开封475000

出　　处：《新中医》2018年第3期139-142,共4页New Chinese Medicine

摘　　要：目的:观察加味茵陈蒿汤联合顺铂腔内灌注治疗肝癌合并腹水的疗效及其对自然杀伤细胞(NK)的影响。方法:将肝癌合并腹水患者90例随机分为2组各45例。对照组采用顺铂腹腔注射进行化疗,治疗组在化疗方案的基础上口服加味茵陈蒿汤。于治疗前后进行中医证候评分及采血检测谷草转移酶(AST)、谷丙转氨酶(ALT)、甲胎蛋白(AFP);检测外周血单个核细胞(PBMC)的NK细胞活力;检测治疗前后腹水的CD4^+/CD8^+,NK细胞计数及NK细胞活力。结果:治疗后,中医证候疗效总有效率治疗组68.9%,对照组42.2%,2组中医证候疗效比较,差异有统计学意义(P<0.05)。治疗后,2组血AST、ALT、AFP,腹腔积液CD4^+/CD8^+、NK细胞计数分别与治疗前比较,差异均有统计学意义(P<0.05,P<0.01)。治疗组AST、ALT、AFP,腹腔积液CD4^+/CD8^+、NK细胞计数均低于对照组,差异均有统计学意义(P<0.05,P<0.01)。结论:加味茵陈蒿汤可以减轻肝癌性腹水患者的症状,增强NK细胞的活力,有较好的临床疗效。objective：To observe the clinical effect of modified Yinchenhao tang combined with cisplatin intraperitoneal perfusion for ascites hepatoma and effect on natural killer cell（NK）. Methods：Divided 90 cases of patients with liver cancer merged with ascites into two groups,45 cases in each group. The control group received cisplatin peritoneal injection for chemotherapy,while the treatment group was given oral administration of modified Yinchenhao tang. Evaluated Chinese medicine syndromes before and after treatment,and collected blood to detect aspartate transferase（AST）,alanine transferase（ALT）,and alpha-fetoprotein（AFP）,to detect NK cell activity of peripheral blood mononuclear cells（PBMC）,and to detect CD4-＋/CD8-＋ of ascites,NK cell count before and after treatment. Results：After treatment,the total effective rate of curative effect of Chinese medicine syndrome was 68.9% in the treatment group and 42.2% in the control group,difference being significant（P〈0.05）. After treatment,differences were significant when respectively compared AST,ALT,AFP,CD4-＋/CD8-＋ of ascites,NK cell count in both groups with those before teatment（P〈0.05,P〈0.01）. Conclusion：Modified Yinchenhao tang can reduce the symptoms of patients with ascites hepatoma and enhance the vitality of NK cells. It has a significant clinical effect.

关 键 词：肝癌性腹水 茵陈蒿汤 自然杀伤细胞活力 谷草转移酶(AST) 谷丙转氨酶(ALT) 甲胎蛋白(AFP) 

分 类 号：R442.5[医药卫生—诊断学]