舒肝解郁胶囊对围绝经期失眠妇女血清FSH、IL-1β及5-HT的影响  

Effects of Liver-soothing Depression-relieving Capsules on FSH,IL-1β and 5-HT in the Serum of Female Patients with Menopausal Insomnia

作　　者：张耕源 张建春 谢娜 孙亚平 王彩娟[4] ZHANG Gengyuan;ZHANG Jianchun;XIE Na;SUN Yaping;WANG Caijuan(Yixian County Hospital, Baoding 071000, China;North China University of Science and Technology;Dingzhou Municipality TCM Hospital;Shijiazhuang Municipality TCM Hospital)

机构地区：[1]易县医院,河北保定071000 [2]华北理工大学 [3]河北省定州市中医医院 [4]石家庄市中医院

出　　处：《西部中医药》2018年第4期5-9,共5页Western Journal of Traditional Chinese Medicine

基　　金：河北省自然科学基金项目(编号303453)

摘　　要：目的:探讨舒肝解郁胶囊对更年期失眠妇女血清促卵泡激素(FSH)、白介素1β(IL-1β)及5-羟色胺(5-HT)的影响。方法:将76例肝郁型围绝经期失眠女性,按1∶1比例随机分为对照组、观察组,每组38例。对照组予艾司唑仑、谷维素治疗,观察组予舒肝解郁胶囊治疗。检测2组血清性激素、细胞因子及单胺类神经递质水平,应用多导睡眠图(PSG)评价睡眠质量,比较临床效果。结果:与治疗前比较,对照组促卵泡激素(FSH)、黄体生成素(LH)、雌二醇(E_2)无变化,差异无统计学意义(P>0.05),观察组FSH、LH明显降低(P<0.01),E_2升高(P<0.01);2组IL-1β、肿瘤坏死因子α(TNF-α)、5-HT、β-内啡肽(β-EP)均升高(P<0.01),5-羟吲哚乙酸(5-HIAA)降低(P<0.01),睡眠潜伏期(SL)、觉醒次数(AT)、觉醒时间(AWT)、REW睡眠潜伏期(RL)降低(P<0.01),睡眠效率(SE)升高(P<0.01),S_1降低(P<0.01),S_2、S_3+S_4、快波睡眠(REM)升高(P<0.01)。与对照组比较,观察组FSH、LH较低(P<0.01),E_2较高(P<0.01),IL-1β、TNF-α较高(P<0.01),5-HT、β-EP较高(P<0.01),5-HIAA较低(P<0.01),SL、AT、AWT、RL均较低(P<0.01),SE较高(P<0.01),S_1较低(P<0.01),S_2、S_3+S_4、REM较高(P<0.01),总有效率较高(P<0.05)。结论:中药舒肝解郁胶囊通过调节FSH、IL-1β、5-HT等机制,从而改善更年期失眠女性睡眠质量。Objective：To discuss the effects of liver-soothing depression-relieving capsules on follicle stimulating hormone（FSH）,interleukin-1β（IL-1β）and 5-hydroxytryptamine（5-HT）in the serum of female with menopausal insomnia.Methods：All 76 patients suffering menopausal insomnia of liver depression pattern were separated into the control group and the observation group randomly according to the ratio of 1∶1,38 cases each group.The patients in the control group were given estazolam and oryzanol,and the ones in the observation group liver-soothing depression-relieving capsules.The levels of sex hormone,cytokines and monoamine neurotransmitter were detected,clinical effects were compared and sleep quality was assessed by using polysomnogram（PSG）.Results：Compared with before treating,FSH,luteinizing hormone（LH）,estradiol（E2）in the control group showed no change,and the difference had no statistical meaning（P〉0.05）,the levels of FSH and LH in the observation group lowered notably（P〈0.01）,E2rose（P〈0.01）;the levels of IL-1β,TNF-α,5-HT andβ-endorphin（β-EP）in both groups raised（P〈0.01）,5-hydroxyindoleacetic acid（5-HIAA）decreased（P〈0.01）,sleep latency（SL）,awakening times（AT）,awakening time（AWT）,REM sleep latency（RL）lowered（P〈0.01）,sleep efficiency（SE）lifted（P〈0.01）,S1decreased（P〈0.01）,S2,S3＋S4and REM evaluated（P〈0.01）.Compared with the control group,the levels of FSH and LH were lower in the observation group（P〈0.01）,E2raised（P〈0.01）,the levels of IL-1βand TNF-αwere higher（P〈0.01）,the levels of5-HT andβ-EP were higher（P〈0.01）,the level of 5-HIAA was lower（P〈0.01）,SL,AT,AWT and RL were lower（P〈0.01）,SE was higher（P〈0.01）,S1was lower（P〈0.01）,S2,S3＋S4and REM were higher（P〈0.01）,total effective rate was higher（P〈0.05）.Conclusion：Liver-soothing depression-relieving capsules could improve sleep quality of female with menopausal insomnia by regulating FS

关 键 词：围绝经期失眠 舒肝解郁胶囊 促卵泡激素 白介素1Β 5-羟色胺 

分 类 号：R271.116[医药卫生—中医妇科学]