急性心力衰竭患者血浆Ghrelin水平与心衰严重程度的关系  

Relationship between the plasma Ghrelin level and the severity of heart failure in patients with acute heart failure

作　　者：肖华贞[1] 黄峰[2] 邓潮超 朱鹏立[2] XIAO Huazhen;Huang Feng;Deng Chaochao;ZHU Pengli(Department of Cardiogogy, Fujian Provincial Hospital, Fuzhou, Fujian 350001 , China)

机构地区：[1]福建省立医院心内科,福州350001 [2]福建医科大学省立临床医学院福建省立医院老年科福建省临床老年病研究所

出　　处：《福建医药杂志》2018年第2期3-7,共5页Fujian Medical Journal

基　　金：福建省科技计划社会发展引导性(重点)项目(2015Y0003)

摘　　要：目的研究急性心力衰竭患者血浆Ghrelin水平与心衰严重程度相关性。方法入选2014年6月至2015年1月福建省急救中心连续入院的急性心衰患者194例,选择健康人群49例作为对照组。采用酶联免疫吸附法测定血浆Ghrelin水平,记录病史及临床体征,测定N末端B型利钠肽原(NT-proBNP)、红细胞比容(HCT)、随机血糖、血脂、左心室射血功能(LVEF)等项目。结果 1)心衰患者与健康对照组相比,舒张压、心率、HCT、估计肾小球滤过率(eGFR)、随机血糖、三酰甘油、TC、HDL-C、LDL-C、尿酸差异均有统计学意义(P值均<0.05)。2)急性心衰患者Ghrelin水平较对照组升高。随着临床程度床边分级等级升高,Ghrelin、NT-proBNP水平升高,LVEF水平降低,差异均有统计学意义(P值均<0.05)。3)Spearman相关分析提示,Ghrelin水平与临床程度床边分级、HCT、TC、LDL-C、eGFR、LgNT-proBNP呈正相关(P值均<0.05),与年龄、是否糖尿病呈负相关(P值均<0.05)。4)多元线性回归分析显示,临床程度床边分级、HCT、LDL-C、eGFR、LgNT-proBNP能独立预测Ghrelin水平(P值均<0.05)。结论不同临床程度床边分级的急性心衰患者Ghrelin水平不同,Ghrelin水平可能与急性心衰严重程度有关。Objective To explore the relationship between plasma Ghrelin level and severity of heart failure in patients with acute heart failure.Methods A total of 194 consecutive acute heart failure patients admitted to Fujian Provincial urgentcare center between June 2014 and January 2015 were included,49 healthy people were selected as the control group.The indices including Medical history,clinical signs,amino-terminal pro-brain natriuretic peptide（NT-proBNP）,Hematocrit（HCT）,Blood glucose,Blood lipid,Left ventricular ejection function（LVEF）,the plasma Ghrelin level,were recorded.Results 1.Diastolic blood pressure,heart rate,HCT,estimated glomerular filtration rate（eGFR）,triglyceride,total cholesterol（TC）,high-density lipoprotein（HDL-C）,low density lipoprotein（LDL-C）and uric acid were significantly different between heart failure patients and healthy subjects（all P〈0.05）.2.The Ghrelin level in acute heart failure patients was higher than that in control subjects,As clinical bedside grade increased,the Ghrelin level and NT-proBNP gradually increases,and the LVEF gradually decreased（all P〈0.05）.3.Spearman correlation analysis showed that the Ghrelin level was positively correlated with clinical bedside grade,HCT,TC,LDL-C,eGFR and LgNT-proBNP,and negatively correlated with age and diabetes mellitus（all P〈0.05）.4.Multivariable logistic regression analyses showed that clinical bedside grade,HCT,LDL-C,eGFR,LgNT-proBNP independently predicted the Ghrelin level（all P〈0.05）.Conclusion The Ghrelin level is positively correlated with clinical bedside grade and may be associated with the severity of acute heart failure.

关 键 词：GHRELIN 急性心力衰竭 心衰严重程度 临床程度床边分级 

分 类 号：R541.6[医药卫生—心血管疾病]