血清铁检测在儿童肺部感染性疾病诊疗中的价值  

Clinical value of serum iron in the diagnosis and treatment of children with pulmonary infectious diseases

作　　者：李雪宁[1] 刘颖[1] 成晓君[1] 程士凯[1] 付大军[1] Li Xuening;Liu Ying;Cheng Xiaojun;Cheng Shikai;Fu Dajun.(Department of the Second Pediatrics, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110004 , China)

机构地区：[1]中国医科大学附属第四医院第二儿科,辽宁省沈阳110004

出　　处：《中国基层医药》2018年第7期827-830,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 观察血清铁在支气管肺炎（细菌感染、肺炎支原体感染）治疗前后变化，并对其是否可以作为感染指标在临床应用进行初步探讨。方法 选取81例确诊为支气管肺炎的患儿为研究对象，其中细菌感染40例、肺炎支原体感染41例，对细菌感染组、肺炎支原体感染组患儿治疗前后血清铁水平分别进行比较，以及对两组间血清铁水平进行分析。同时对两组患儿治疗前血常规白细胞数、中性粒细胞比例、CRP水平与血清铁及治疗前后血清铁变化值分别进行相关性分析。结果 细菌感染组血清铁水平治疗后[（16.28±5.81）μmol/L]明显高于治疗前[（4.83±2.12）μmol/L]（t＝－11.19，P〈0.001），肺炎支原体感染组血清铁水平治疗后[（15.17±5.31）μmol/L]同样明显高于治疗前[（4.77±1.99）μmol/L]（t＝－11.29，P〈0.001）。治疗前两组间血清铁水平、治疗后两组间血清铁水平差异均无统计学意义（t＝0.135、0.898，P＝0.893、0.373）。治疗前血常规白细胞数、中性粒细胞比例、CRP与治疗前血清铁（细菌感染组r值分别为－1.87、－0.219、－0.152；肺炎支原体感染组r值分别为－0.032、－0.302、－0.274）及治疗前后变化值（细菌感染组r值分别为0.098、0.062、0.205；肺炎支原体感染组r值分别为0.011、0.171、－0.105）均无相关性（均P〉0.05）。结论 血清铁在儿童肺部感染时出现明显下降，抗感染治疗后恢复至正常水平。血清铁尚不能作为儿童感染监测指标应用于临床。Objective To observe the changes of serum iron in patients with bronchopneumonia（bacterial pneumonia,mycoplasmal pneumonia）before and after treatment,and to discuss whether it can be used as an indicator of infection.Methods Forty cases with bacterial pneumonia and 41 cases with mycoplasmal pneumonia were recruited.The serum iron levels before and after treatment in bacterial pneumonia group and mycoplasmal pneumonia group were compared and analyzed.The correlation between white blood cell count,percentage of neutrophils,serum C-reactive protein（CRP）levels and the serum iron levels before treatment,and changes of the serum iron before and after treatment were analyzed.Results The level of serum iron after treatment in the bacterial pneumonia group[（16.28±5.81）μmol/L]was significantly higher than that before treatment[（4.83±2.12）μmol/L]（t=-11.19,P〈0.001）.The level of serum iron after treatment in the mycoplasmal pneumonia group[（15.17±5.31）μmol/L]was also significantly higher than that before treatment[（4.77±1.99）μmol/L]（t=-11.29,P〈0.001）.The serum iron levels between the two groups before and after treatment had no statistically significant differences（t=0.135,0.898,P=0.893,0.373）.There was no correlation between white blood cell count,percentage of neutrophils,CRP and serum iron levels before treatment（bacterial pneumonia group：r=-1.87,-0.219,-0.152;mycoplasmal pneumonia group：r=-0.032,-0.302,-0.274）and changes of the serum iron before and after treatment（bacterial pneumonia group：r=0.098,0.062,0.205;mycoplasmal pneumonia group：r=0.011,0.171,-0.105,P〉0.05）.Conclusion The serum iron level is significantly decreased in children with pulmonary infectious diseases and increased to normal level after anti-infection treatment.Serum iron can not be used as an indicator of infection in children.

关 键 词：支气管肺炎 血清铁 儿童 

分 类 号：R725.6[医药卫生—儿科]