热毒宁治疗疱疹性咽峡炎患儿的临床评价和对血清肌酸激酶、磷酸肌酸激酶同工酶活性及其质量、心肌肌钙蛋白I的影响研究  

Clinical effect of Reduning in the treatment of children with herpangina and its influence on serum creatine kinase（CK）,CK-MB activity,CK-MB quality,cTnI

作　　者：叶卫平 Ye Weiping.(Department of Pediatrics, Taizhou Hospital of Traditional Chinese Medicine, Taizhou Zhefiang 318000, China)

机构地区：[1]台州市中医院儿科,浙江省台州318000

出　　处：《中国基层医药》2018年第7期838-841,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省中医药科技计划项目（2015A079）

摘　　要：目的 探讨热毒宁治疗疱疹性咽峡炎患儿的临床效果及其对血清肌酸激酶（CK）、磷酸肌酸激酶同工酶（CK-MB）活性、CK-MB质量、心肌肌钙蛋白I（cTnI）的影响。方法 选择疱疹性咽峡炎患儿104例，采用抽签法分为对照组与研究组，每组52例。对照组采用常规治疗，研究组在对照组治疗的基础上加用热毒宁治疗，比较两组临床疗效，临床表现消失时间，治疗前后CK、CK-MB活性、CK-MB质量、cTnI和不良反应。结果 研究组总有效率高于对照组（98.07%比84.61%），差异有统计学意义（P〈0.05）。治疗前，两组CK、CK-MB活性、CK-MB质量、cTnI差异均无统计学意义（P〉0.05）；治疗后，研究组CK、CK-MB活性、CK-MB质量、cTnI低于对照组[（55.87±6.98）U/L、（22.70±2.84）U/L、（2.99±0.37）μg/L、（0.16±0.02）μg/L比（68.42±8.55）U/L、（29.45±3.65）U/L、（4.48±0.56）μg/L、（0.74±0.09）μg/L]，差异均有统计学意义（均P〈0.05）。研究组不良反应率低于对照组，差异有统计学意义（P〈0.05）。结论 热毒宁治疗疱疹性咽峡炎患儿的临床效果肯定，能够利于临床表现的缓解，降低血清CK、CK-MB活性、CK-MB质量、cTnI，且可缓解机体炎性反应及提高免疫功能。Objective To explore the clinical effect of Reduning in the treatment of children with herpangina,and its influence on serum creatine kinase（CK）,creatine phosphate kinase isoenzyme（CK-MB）activity,CK-MB quality,cardiac troponin I（cTnI）.Methods 104 children with herpangina were divided into control group and research group according to the draw method,with 52 cases in each group.The control group was given conventional treatment,the research group was treated with Reduning on the basis of conventional treatment.The clinical curative effect,clinical symptoms disappear time,CK,CK-MB activity,CK-MB quality,inflammation factors,immune function before and after treatment,and adverse reactions were compared between the two groups.Results The total effective rate of the research group was higher than that of the control group（98.07% vs.84.61%）,the difference was statistically significant（P〈0.05）.Before treatment,the CK,CK-MB activity,CK-MB quality,cTnI of the two groups had no statistically significant differences（all P〉0.05）.After treatment,the CK,CK-MB activity,CK-MB quality,cTnI of the research group were lower than those of the control group[（55.87±6.98）U/L vs.（68.42±8.55）U/L,（22.70±2.84）U/L vs.（29.45±3.65）U/L,（2.99±0.37）μg/L vs.（4.48±0.56）μg/L,（0.16±0.02）μg/L vs.（0.74±0.09）μg/L],the differences were statistically significant（all P〈0.05）.The incidence rate of adverse reaction of the research group was lower than that of the control group,the difference was statistically significant（P〈0.05）.Conclusion The clinical effect of Reduning in the treatment of children with herpangina is sure,it can help to relieve clinical manifestations,reduce serum levels of CK,CK-MB activity,CK-MB quality,cTnI,and can alleviate the body＇s inflammatory response and immune function.

关 键 词：疱疹性咽峡炎 热毒宁 肌酸激酶 磷酸肌酸激酶同工酶活性 CK-MB质量 心肌肌钙蛋白I 

分 类 号：R276.1[医药卫生—中医五官科学]