荆州地区肺炎链球菌流行特点的回顾性研究  

A retrospective study on the epidemic characteristics of Streptococcus pneumoniae in Jingzhou area

作　　者：于会娜[1] 付强[1] 晏霞[1] 周云 屈悦 王婷 周义正[2] 杨严 YU Huina;FU Qiang;YAN Xia;ZHOU Yun;QU Yue;WANG Ting;ZHOU Yizheng;YANG Yan(Department of Pediatrics;Department of Clinical Laboratory, Jingzhou Central Hospital,Jingzhou Hubei 434000, China)

机构地区：[1]荆州市中心医院儿科,湖北荆州434000 [2]荆州市中心医院检验科,湖北荆州434000

出　　处：《临床与病理杂志》2018年第3期570-574,共5页Journal of Clinical and Pathological Research

摘　　要：目的:了解荆州地区肺炎链球菌患儿分离株的流行特点,为临床经验治疗提供依据。方法:2015年1月至2016年12月荆州市中心医院儿科(除外新生儿科)送检痰培养标本3 415例,共检出肺炎链球菌菌株342例,其中男200例(58.48%),女142例(41.52%)。分析肺炎链球菌的临床分布资料及对各种抗菌素的耐药情况。结果:肺炎链球菌女性患儿的检出率和男性患儿差别不大;肺炎链球菌主要感染5岁以下患儿,季节以冬春季节为主;尚未检出耐万古霉素和利奈唑胺的肺炎链球菌;肺炎链球菌对左氧氟沙星、莫西沙星、厄他培南、氯霉素、氧氟沙星、泰利霉素的敏感性较高;对复方新诺明、四环素、红霉素、青霉素的耐药率较高;美罗培南中介;阿莫西林、头孢噻肟、头孢曲松仍有较高的敏感性。结论:在荆州地区,阿莫西林、头孢噻肟、头孢曲松仍可作本地区肺炎链球菌感染的非脑膜炎的临床一线用药,对于高耐药菌株和重症感染时可以使用万古霉素和利奈唑胺。Objective： To investigate the epidemiological characteristics of isolates of Streptococcus pneumoniae in Jingzhou area, and to provide evidence for clinical experience. Methods： A total of 3 415 cases of Streptococcus pneumoniaewere detected in pediatric pediatric department（except neonates） from January 2015 to December 2016. A total of 342 strains of Streptococcus pneumoniae were detected, including 200 males, accounting for 58.48%; 142 females, accounting for 41.52%. The clinical data of Streptococcus pneumoniae and the resistance to various antibiotics were analyzed. Results： The detection rate of children with Streptococcus pneumoniae was not different from that of male children. Streptococcus pneumoniae mainly infected children under 5 years of age, seasonal distribution mainly in winter and spring; Streptococcus pneumoniae resistant to vancomycin and linezolid has not been detected; Streptococcus pneumoniae was more sensitive to levofloxacin, moxifloxacin, etanilapine, chloramphenicol, ofloxacin and telithromycin; and highly resistant to cotrimoxazole, tetracycline, erythromycin, penicillin; meropenem intermediates; amoxicillin, cefotaxime, ceftriaxone was still a high sensitivity. Conclusion： Amoxicillin, cefotaxime and ceftriaxone can be used as a clinical first-line drug for non-meningitis in Streptococcus pneumoniaeinfection in Jingzhou area. For high-resistant strains and severe infection, vancomycin and Linezolid.

关 键 词：肺炎链球菌 儿童 荆州地区 

分 类 号：R446.5[医药卫生—诊断学] R725.6[医药卫生—临床医学]