甘露糖结合凝集素补体途径与糖尿病肾病的相关性的研究进展  

Research progress on the relationship between mannose binding lectin complement pathway and diabetic nephropathy

作　　者：陈春雷[1] 刘晓刚[1] 禹程远[2] 梁慧 袁福才 解汝娟[1] CHEN Chunlei;LIU Xiaogang;YU Chengyuan;LIANG Hui;YUAN Fucai;XIE Rujuan(Department of Nephrology;Department of Geriatrics;Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin 150000, China)

机构地区：[1]哈尔滨医科大学附属第一医院肾内科,哈尔滨150000 [2]哈尔滨医科大学附属第一医院老年病科,哈尔滨150000 [3]哈尔滨医科大学附属第一医院心血管内科,哈尔滨150000

出　　处：《临床与病理杂志》2018年第3期618-622,共5页Journal of Clinical and Pathological Research

基　　金：国家自然科学基金(81670659)~~

摘　　要：糖尿病肾病是糖尿病最严重的微血管并发症,是终末期肾病的重要病因之一。甘露糖结合凝集素(mannose-binding lectin,MBL)是糖尿病肾病发生发展重要的生物标志物,H型纤维胶原凝集素(H-ficolin)也与糖尿病肾病的发展有关,而MBL相关丝氨酸蛋白酶与糖尿病肾病的关系有待进一步研究。Diabetic nephropathy is one of the most important microvascular complications of diabetes, and is a significant cause of end-stage renal disease. There is evidence that the mannose binding lectin（MBL） has become a common development biomarker of diabetic nephropathy, and H-ficolin is also associated with the development of diabetic nephropathy, but the relationship between MBL associated serine protease and diabetic nephropathy remains to be further studied.

关 键 词：糖尿病肾病 甘露糖结合凝集素 H型纤维胶原凝集素 甘露糖结合凝集素相关丝氨酸蛋白酶 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]