呼吸机相关性膈肌功能不全发生机制研究进展  

Progress in pathogenesis of ventilator induced diaphragmatic dysfunction

作　　者：王云霞[1] 周天瑜[1] 孙超[1] 钟益珏[1] 张红[1] 王广发[1] Wang Yunxia;Zhou Tianyu;Sun Chao;Zhong Yijue;Zhang Hong;Wang Guangfa(Department of Respiratory and Critical Care Medicine, the First Hospital, Peking University, Beijing 100034, China)

机构地区：[1]北京大学第一医院呼吸和危重症医学科,100034

出　　处：《国际呼吸杂志》2018年第7期557-560,共4页International Journal of Respiration

基　　金：国家自然科学基金（81370106）;北京市自然科学基金（7132187）

摘　　要：机械通气是呼吸衰竭患者必不可少的生命支持手段。然而，机械通气是一把双刃剑，在挽救患者生命的同时，也会有许多并发症发生，其中就包括呼吸机相关性膈肌功能不全，这在动物实验及人体研究中都经过明确验证，并且是通过抑制蛋白合成及增强蛋白分解两种方式共同作用，合成及水解这两种方式均受多种机制调节，其中蛋白水解作用更大。Mechanical ventilation is an essential means of life support for patients with respiratory failure. However, mechanical ventilation is a double-edged sword, there are many complications while saving patients＇ lives, which including ventilator-induced diaphragmatic dysfunction （VIDD）. VIDD has been confirmed in animal and human studies through two ways of inhibiting protein synthesis and enhancing proteolysis. Both protein synthesis and hydrolysis are regulated by a variety of mechanisms, and proteolysis is more important during the VIDD progress.

关 键 词：呼吸机相关性膈肌功能不全 蛋白水解 蛋白合成 

分 类 号：R563.9[医药卫生—呼吸系统]