降钙素原与C-反应蛋白对哮喘合并呼吸道感染患者的诊断及治疗意义  

Diagnostic and therapeutic significance of procalcitonin and C-reactive protein in patients with asthma complicated with respiratory tract infections

作　　者：方琪[1] 崔益明[2] 章幽芳[3] 郑和豪[4] 叶安[2] FANG Qi;CUI Yi-ming;ZHANG You-fang;ZHENG He-hao;YE An(The Quzhou People＇s Hospital, QuZhou, Zhejiang 324000, Chin)

机构地区：[1]衢州市人民医院呼吸内科,浙江衢州324000 [2]衢州市人民医院急诊科,浙江衢州324000 [3]衢州市人民医院儿科,浙江衢州324000 [4]衢州市人民医院心电图科,浙江衢州324000

出　　处：《中华医院感染学杂志》2018年第7期1005-1007,1011,共4页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生基金资助项目(2014KYA170)

摘　　要：目的浅析降钙素原(PCT)与C-反应蛋白(CRP)对哮喘合并呼吸道感染患者诊断及治疗意义。方法选择于2016年1月-2017年2月医院呼吸科收治的哮喘患者63例,根据患者感染情况分为单纯哮喘组19例、哮喘合并病毒感染组15例及哮喘合并细菌感染组29例。治疗前抽取患者清晨空腹静脉血进行血清PCT及CRP检测,分析三组患者PCT及CRP表达水平及检测阳性情况,并随访记录患者发生呼吸衰竭情况。结果哮喘合并细菌感染组及哮喘合并病毒感染组的血清PCT及CRP表达水平均高于单纯哮喘组,哮喘合并细菌感染组PCT及CRP表达水平均高于合并病毒感染组(P<0.05);哮喘合并细菌感染组PCT及CRP阳性率分别为79.31%、82.76%,均高于单纯哮喘组(P<0.05);发生呼吸衰竭组PCT表达水平为(6.93±1.94)ug/L,高于未发生呼吸衰竭组(P<0.05)。结论血清PCT和CRP水平可反映哮喘合并呼吸道感染患者的感染情况,指导临床抗感染药物的选择及对疾病预后具有一定价值。OBJECTIVE To investigate the diagnostic and therapeutic significance of procalcitonin（PCT）and C-reactive protein（CRP）in patients with asthma complicated with respiratory tract infection.METHODS All cases were selected from 63 asthma patients from Jan.2016 to Feb.2017.According to the infection status of the patients,the patients were divided into asthma group（19 cases）,combined virus infection group（15 cases）and combined bacterial infection group（29 cases）.Before treatment,fasting venous blood was taken from patients in early morning to detect serum PCT and CRP.The levels of PCT and CRP expression levels and positive detection in three groups were analyzed,and follow-up records of respiratory failure in patients were recorded.RESULTS The serum PCT and CRP levels of the combined bacterial infection group and the combined virus infection group were significantly higher than those of asthma group,and those of combined bacterial infection group were significantly higher than those of the combined virus infection group（P〈0.05）.The positive rates of PCT and CRP in combined bacterial infection group were 79.31% and 82.76%,which significantly higher than those in asthma group（P〈0.05）.The expression level of CRP in respiratory failure group was were higher than that in non-respiratory failure group（P〈0.05）.CONCLUSIONThe serum PCT and CRP levels can reflect the infection of asthma patients with respiratory tract infections,which has a certain value to guide the selection of clinical anti-infective drugs,and for the prognosis of the disease.

关 键 词：降钙素原 C-反应蛋白 哮喘合并呼吸道感染 诊断 治疗 

分 类 号：R56[医药卫生—呼吸系统]