氟哌啶醇片红外光谱鉴别的方法改进  

Improvement of Method for the Identification of Haloperidol Tablets by Infrared Spectrometry

作　　者：袁哲[1] 尹燕杰[1] 张昊天[1] Yuan Zhe, et al(Harbin Institute.for Food and Drug Control,Harbin, 150525)

机构地区：[1]哈尔滨市食品药品检验检测中心,哈尔滨150525

出　　处：《黑龙江医药》2018年第2期237-238,共2页Heilongjiang Medicine journal

摘　　要：目的:寻找一种适宜的样品处理方法,去除脂溶性杂质对氟哌啶醇红外光谱鉴别的干扰。方法:以三氯甲烷为溶剂从氟哌啶醇片中提取出样品,氯仿层经高速离心,过滤,水浴蒸干后,残渣经少量乙醚洗涤,再与溴化钾混合压片。结果:处理后的样品图谱与标准图谱匹配度高。结论:该方法操作简单,结果可靠。Objective：To improve the method of Haloperidol Tablets by Infrared Spectrometry to remove the interference. Method： The sample was abstracted by CH3 Cl3,then was centrifugated, filtered and steamed, at last was washed by（C2 H5）2 O. Results：The method is simple and effective, the infrared absorption spectroscopies were perfect matching. Conclusions： To identify the Haloperidol Tablets,it is necessary to wash the steamed residue by（C2 H5）2 O to remove the fat-soluble impurities.

关 键 词：氟哌啶醇 萃取 溴化钾压片 红外吸收光谱法 

分 类 号：R927.2[医药卫生—药学]