基于ABC外排蛋白介导的中药七情配伍的药动学机制研究进展  

Pharmacokinetics mechanism of ABC efflux proteins-mediated seven features of compatibility

作　　者：杨珅珅[1] 刘安丽 单兰兰[1] 曾桐春 周倩[1] 李遇伯[1] YANG Shen-shen;LIU An-li;SHAN Lan-lan;ZENG Tong-chun;ZHOU Qian;LI Yu-bo(Tianjin University of Traditional Chinese Medicil~e, Tianjin 300195, China;Pharmacy College, Ningxia Medical University, Yinchuan 750004, China)

机构地区：[1]天津中医药大学,天津300193 [2]宁夏医科大学药学院,宁夏银川750004

出　　处：《中国中药杂志》2018年第4期676-683,共8页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金面上项目(81573825);教育部“创新团队发展计划”项目(IRT-14R41)

摘　　要：ABC外排蛋白是一类依赖ATP水解释放的化学能，介导机体多种内源性和外源性外排蛋白底物的跨膜转运。其广泛存在于人体的各种组织器官中，是人体内重要的功能性膜蛋白。药物改变转运蛋白的表达和（或）功能，将会影响该转运蛋白对应底物药物的体内处置过程，产生药动学方面的相互作用。外排蛋白主要由P．糖蛋白（P-glyeoprotein，P-gP）、多药耐药相关蛋白（multidrug resistance associated protein，MRP）、乳腺癌耐药蛋白（breast cancer resistance protein，BCRP）组成，能够对药物在体内的吸收、分布、代谢、排泄过程产生影响。药物对外排蛋白的诱导或抑制作用是中药配伍使用时产生相互作用的重要因素，这种作用可能是七情配伍理论的重要机制之一。该文就七情配伍对ABC外排蛋白的影响进行了简要综述，以揭示外排蛋白在药对配伍中的作用．为中药配伍机制和合理性提供新思路。ABC efflux proteins are a kind of transporters mediating diversified endogenous and exogenous effiux protein substrates across the plasma membrane by depending on the chemical energy released by ATP hydrolysis. As a vitally important functional mem- brane, it is widely found in various tissues and organs. The drug changes the expressions and/or funetions of the transport proteins, which will affect the disposal process of substrate drugs corresponding to transporters in vivo, and finally lead to the pharmacokinetic in- teractions. The effiux proteins take part in the absorption, distribution, metabolism and excretion of drugs, and mainly consist of P-gly- coprotein （P-gp）, multidrug resistance associated protein （MRP） and breast cancer resistance protein （BCRP）. The induction effect or inhibition effect of drugs on efflux protein plays a greatly significant role in the drug interaction produced by the compatibility of tradi- timlal Chinese medicine, which may be one of the important mechanisms of the theo13＇ of seven ieatures of compatibility. In this article, the effects of seven features of compatibility on file ABC effiux transporters were reviewed, in order to reveal the roles of efflux protein in the herb-pairs compatibility, and provide new ideas for the mechanism and rationality of herb compatibility.

关 键 词：ABC外排蛋白 中药配伍 抑制 诱导 

分 类 号：R285[医药卫生—中药学]