甲钴胺联合神经节苷酯治疗慢性酒精中毒性周围神经病的临床研究  

Clinical study of mecobalamin combined with ganglioside in the treatment of chronic alcoholic peripheral neuropathy

作　　者：栾慧英[1] Luan Huiying(Department of Electrophysiology , Laizhou People＇ s Hospital, Laizhou 261400, China)

机构地区：[1]山东省莱州市人民医院电生理科,261400

出　　处：《中国实用医刊》2018年第6期121-124,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析甲钴胺联合神经节苷酯治疗慢性酒精中毒性周围神经病的临床疗效。 方法选取84例慢性酒精中毒性周围神经病患者作为本次研究对象，将其按治疗方法不同分为观察组（甲钴胺联合神经节苷酯治疗）与对照组（仅使用甲钴胺进行治疗），每组42例。84例患者均自愿参与本次研究。记录并比较两组患者的治疗总有效率、治疗前后的神经传导速度、不良反应发生率、治疗满意度。 结果观察组治疗总有效率显著高于对照组（P〈0.05）；治疗前，两组患者的神经传导速度比较差异未见统计学意义（P〉0.05），治疗后，观察组患者的神经传导速度显著优于对照组患者（P〈0.05）；两组患者均出现了不同程度的不良反应，差异未见统计学意义（P〉0.05）；观察组的治疗满意度为（95.23±2.11）分，对照组的治疗满意度为（75.23±4.14）分，组间比较差异有统计学意义（P〈0.05）。 结论慢性酒精中毒性周围神经病患者使用甲钴胺联合神经节苷酯进行治疗，可显著提高治疗总有效率，用药安全性得以保障，患者的神经传导速度得到优化，使其能够快速恢复正常生活，患者治疗满意度高，值得临床推广应用。ObjectiveTo analyze the clinical effect of mecobalamin combined with ganglioside on chronic alcoholic peripheral neuropathy. MethodsEighty-four cases of chronic alcohol peripheral neuropathy were selected as the subjects of this study, according to the different treatment methods, they were divided into the observation group （treated with mecobalamin combined with ganglioside） and control group （only treated with mecobalamin）, each group of 42 patients, Eighty-four patients were voluntarily involved in this study. The total effective rate of treatment, the nerve conduction velocity before and after treatment, the incidence of adverse reactions, and the satisfaction of treatment were recorded and compared in the two groups. ResultsIn the observation group, the total effective rate was significantly higher than that of the control group （P〈0.05）; before the treatment, the nerve conduction velocity of two groups showed no significant difference （P〉0.05）, after treatment, the nerve conduction velocity in observation group were significantly better than that of the control group （P〈0.05）; the two groups all had adverse reactions, but there was no significant difference between the two groups （P〉0.05）; the treatment satisfaction was （95.23±2.11） points in the observation group, and the treatment satisfaction was （75.23±4.14） in the control group, the difference was significant （P〈0.05）. ConclusionsChronic alcoholic peripheral neuropathy patients using mecobalamin combined with ganglioside treatment, can significantly improve the total efficiency of treatment, the safety of drug use is guaranteed, nerve conduction velocity were optimized, which can quickly return to normal life, patients with a high degree of satisfaction, it is worthy of clinical application.

关 键 词：神经传导速度 甲钴胺 神经节苷酯 慢性酒精中毒性周围神经病 

分 类 号：R595.6[医药卫生—内科学]