细胞自噬对腰椎间盘突出后重吸收的意义  

Significance of cell autophagy in resorption of lumbar disc herniation

作　　者：刁志君 姜宏[2] 刘锦涛[2] DIAO Zhi-jun;JIA NG Hong;LIU Jin-tao(Department of Orthopaedics, Hospital of Tradctiona! Chinese Medicine of Suzhou City, Suzhou 215001, China)

机构地区：[1]上海中医药大学,上海201203 [2]苏州市中医医院骨科,江苏苏州215001

出　　处：《中国骨伤》2018年第4期386-390,共5页China Journal of Orthopaedics and Traumatology

摘　　要：细胞自噬作为细胞的一种自我保护性机制,可通过降解自身衰老物质而维持细胞稳定,且可被高度诱导,自噬对细胞的降解能力会随年龄的增加而减弱。腰椎间盘突出后的重吸收现象是临床保守治疗腰椎间盘突出症患者有效的机制之一,退行性病变是腰椎间盘突出的主要原因之一,细胞自噬又广泛参与了腰椎间盘的退行性病变,并延缓了退行性病变的发生,同时细胞自噬可潜在性诱导重吸收现象的发生。细胞自噬的研究对椎间盘退行性病变以及腰椎间盘突出后的重吸收现象意义重大,对临床保守治疗腰椎间盘突出症患者具有指导意义,因此应重视细胞自噬在重吸收现象中的研究。As a self protective mechanism of cells,autophagy of cells can maintain cell stability by degrading self aging substances,and it can be highly induced. The ability of autophagy to degraded cells will decrease with age. The resorption phenomenon after lumbar disc herniation is one of the effective mechanisms in conservative treatment of lumbar disc herniation.The degenerative lesion of intervertebral disc is one of the main reasons of lumbar disc herniation. Cell autophagy is extensive participation in the degeneration of lumbar intervertebral disc,delaying the occurrence of degenerative disease. Futhermore,cell autophagy can potentially induce the occurrence of reabsorption. The study of cell autophagy has great significance to the degenerative disease of intervertebral disk and the reabsorption of lumbar disc herniation. And it is also of great significance for the clinical treatment of patients with lumbar disc herniation. For this reason,we should pay more attention to the study of cell autophagy in resorption.

关 键 词：椎间盘移位 重吸收 椎间盘退行性改变 细胞自噬 综述文献 

分 类 号：R681.5[医药卫生—骨科学]