实验性偏头痛动物模型的应用评价与中医药治疗探讨  

Application and Evaluation of Experimental Migraine Animal Model and Treatment of Traditional Chinese Medicine

作　　者：宋慧荣[1] 任小巧[1] 罗亚敏[1] 李冉 高明慧 顿珠[2] 陶晓华[1,2] Song Huirong;Ren Xiaoqiao;Luo Yamin;Li Ran;Gao Minghui;Dun Zhu;Tao Xiaohua(Beijing University of Chinese Medicine, Beijing 100029, China;Tibet College of Medicine, Lhasa 850000, China)

机构地区：[1]北京中医药大学,北京100029 [2]西藏藏医学院,拉萨850000

出　　处：《世界科学技术-中医药现代化》2018年第1期73-77,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：西藏自治区科技厅重点项目(2015XEOIG68):藏药如意珍宝丸干预偏头痛的药效学研究;负责人:陶晓华

摘　　要：本文主要目的是评价中医药研究中实验性偏头痛动物模型选择的合理性,提出合理选择动物模型的建议。采用文献分析方法,结合中医药对偏头痛的认识(即不同的偏头痛中医证型采用相应的动物模型和中医药治疗手段),对当前偏头痛动物模型的应用和选择进行分析、评价,探讨模型选择的合理性。目前中医药治疗偏头痛实验研究中动物模型的选择存在一些实际问题,建议在实验研究中选择模型时首先根据要解决的临床问题、研究内容或是研究药物的作用特点来选择恰当的动物模型;在中医药理论的指导下,根据该模型的形成机理和自身特点以及药物的作用特点来选择恰当的药物治疗。This study was aimed to evaluate the rationality of animal model selection of experimental migraine in traditional Chinese medicine（TCM）research,and to propose the reasonable choice of animal model.This study used the method of literature analysis to evaluate the application of animal model and to discuss how to choose it rationally,in combination with TCM understanding on migraine（that is,different TCM syndrome types of migraine model and TCM treatment methods）.It was concluded that there were some suggestions for choice of animal model in the experimental study of migraine,according to clinical problems,research contents or drug characteristics to choose the appropriate animal model as well as the appropriate drug treatment based on the formation mechanism and characteristics of the model and drug characteristics.

关 键 词：偏头痛 动物实验 模型应用 中医药治疗 

分 类 号：R91[医药卫生—药学]