六种钙类矿物药元素谱的X射线荧光光谱法无标样分析  

Standard-less Analysis of Six Kinds of Calcium Mineral Drug Elements by X-Ray Fluorescence Spectrometry

作　　者：孙琳 梁鹏晨 严铸云[1] 彭镰心[1] 陈新[1] 李小翠 SUN Lin;LIANG Peng-chen;YAN Zhu-yun;PENG Lian-xin;CHEN Xin;LI Xiao-cui(Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and Ministry of Science and Technology, Key Laboratory of Standardization of Chinese Herbal Medicine Under Ministry of Education, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China)

机构地区：[1]成都中医药大学药学院中药材标准化省部共建教育部重点实验室四川省中药资源系统研究与开发利用省部共建国家重点实验室培育基地

出　　处：《中国实验方剂学杂志》2018年第9期70-76,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：四川省科技人才培养基金(KD20140816)

摘　　要：目的：检测6种钙类矿物药的元素谱,尝试建立一种粉末状矿物药快速分析和同质性评价的方法。方法：将石膏、钟乳石、花蕊石、紫石英、龙骨、石燕药材粉碎至200目粉末后压片制样,应用X-射线荧光光谱仪的无标样分析方法,从氧到铀元素范围内进行元素谱扫描;以K,L,M谱线强度的平方根为纵坐标,2θ角为横坐标,将匹配后的元素标在图谱上,直观表征矿物药元素谱信息。结果：从6种钙类矿物药中共检出Al,Ca,Er,F,Fe,Ga,K,Mg,Mn,Mo,Na,Nb,O,P,Rb,S,Si,Sr,Ti,W,Y,Zr,Zn,Re,Ba共25种元素;同种矿物药的元素谱较稳定,不同品种间差异明显,其中Ca,F,O,P,S,Si等元素的含量变化较大,Al,Er,Fe,Ga,K,Mo等变化较小;性状特征不符合的3份石膏和1份紫石英,其含量也不符合2015年版《中国药典》要求。结论：X射线荧光光谱法具有操作简单,多元素同时分析、绿色环保等优势,能快速、简便获得矿物药的元素谱信息,可用于粉末状矿物药同质性分析和鉴别。Objective：To study the element spectra of six kinds of calcium mineral drugs,in order to establish a rapid and environmental friendly analytical method to identify the authenticity and quality of mineral drugs powder,including the similar composition samples.Method：In this experiment,samples of Gypsum Fibrosum,Stalactitum,Ophicalcitum,Fluoritum,Os Draconis and Spirifer were crushed to 200-mesh powder.Afterwards the samples were pressed into directly pellets,and determined by X-ray fluorescence standard-less quantitative analysis method.All of the samples were measured within the scope of elements from oxygen to uranium.A method for characterizing the spectral characteristics of mineral elements were established,with the square root of K,L,M line intensity as the vertical coordinate and 2θ angle as the horizontal coordinate.The matched element spectral line coordinates were drawn on the spectra,so as to visually identify the elemental characteristics of medicinal materials.Result：From the six kinds of calcium mineral drug,25 elements,namely Al,Ca,Er,F,Fe,Ga,K,Mg,Mn,Mo,Na,Nb,O,P,Rb,S,Ba,Si,Sr,Zr,Ti,W,Y,Zn and Re,were detected.The element spectra of the same kind calcium mineral drugs were relatively stable,the element spectra of different medicinal materials were obviously different.Among them,the content of Ca,F,O,P,S,Si varied widely,with small changes in Al,Er,Fe,Ga,K,Mo.The content of three Gypsum Fibrosum samples and one Fluoritum sample did not meet the requirement of 2015 edition Chinese Pharmacopoeia.Conclusion：Compared with other methods,X-ray fluorescence spectrometry has the advantages of simple operation,simultaneous analysis of multi-elements and environmental friendliness.It can quickly and easily obtain the elements spectra information of mineral drugs and identify the homogeneity of mineral drug powder.

关 键 词：钙类矿物药 元素谱 X射线荧光光谱 无标分析 

分 类 号：R284.1[医药卫生—中药学] R931.76[医药卫生—中医学]