解毒活血饮联合辛伐他汀片治疗颈动脉粥样硬化疗效观察  

Clinical Observation of Jiedu Huoxue Yin Combined with Simvastatin Tablets for Carotid Atherosclerosis

作　　者：安黎[1] AN Li

机构地区：[1]天台县中医院,浙江天台317200

出　　处：《新中医》2018年第4期53-55,共3页New Chinese Medicine

摘　　要：目的:观察解毒活血饮联合辛伐他汀片治疗颈动脉粥样硬化的疗效。方法:将90例有颈动脉粥样硬化斑块的痰瘀阻络证患者随机分为对照组和观察组各45例。2组均口服辛伐他汀片,观察组加口服解毒活血饮,4周为1疗程,连续用药3疗程。治疗前后检测2组患者的颈动脉内中膜厚度(IMT)、斑块面积及血流参数[舒张末期血流速度(EDV)、收缩峰期血流速度(PSV)、脉动指数(PI)、阻力指数(RI)]的变化。结果:治疗后,2组IMT、斑块面积均较治疗前减少(P<0.05),EDV、PSV均较治疗前增加(P<0.05),2组PI、RI与治疗前比较,差异均无统计学意义(P>0.05);观察组IMT、斑块面积的改善均优于对照组(P<0.05),EDV、PSV值均高于对照组(P<0.05)。结论:在辛伐他汀片治疗基础上加用解毒活血饮有助于减少IMT,缩小动脉粥样硬化斑块,增快颈总动脉血流速度,改善动脉粥样硬化。Objective：To observe the curative effect of Jiedu Huoxue yin combined with simvastatin tablets for carotid atherosclerosis.Methods：Divided 90 patients with carotid atherosclerotic plaque with phlegm-stasis in channels into the control group and the observation group randomly,45 cases in each group.Both groups received simvastatin tablets orally,while the observation group was additionally given oral administration of Jiedu Huoxue yin.Both groups continuously received treatment for 3 courses,4 weeks being one course.Detected carotid intima-media thickness（IMT）,plaque area,and blood flow parameters[end diastolic velocity（EDV）,peak systolic velocity（PSV）,pulsation index（PI）and resistance index（RI）].Results：After treatment,IMT and plaque area in two groups were both decreased when compared with those before treatment（P 0.05）,and EDV and PSV in two groups were both increased when compared with those before treatment（P 0.05）.Compared PT and RI in two groups with those before treatment,there were no significant differences being found（P 0.05）.IMT and plaque area of the observation group were both better than those of the control group（P 0.05）,and EDV and PSV of the observation group were both higher than those of the control group（P 0.05）.Conclusion：The additional application of Jiedu Huoxue yin based on simvastatin tablets therapy can help reducing IMT,the size of atherosclerotic plaque,increasing blood flow velocity in the common carotid artery,and improving atherosclerosis.

关 键 词：动脉粥样硬化斑块 痰瘀阻络证 中西医结合疗法 解毒活血饮 内中膜厚度(IMT) 动脉血流参数 

分 类 号：R543.5[医药卫生—心血管疾病]