活血逐瘀汤治疗子宫腺肌症临床研究  

Clinical Observation of Huoxue Zhuyu Tang for Adenomyosis

作　　者：张玉锋 张炜[1] 张宝丽[1] 高明霞[1] ZHANG Yufeng;ZHANG Wei;ZHANG Baoli;GAO Mingxia

机构地区：[1]兰州大学第一医院,甘肃兰州730000

出　　处：《新中医》2018年第4期121-124,共4页New Chinese Medicine

摘　　要：目的:观察活血逐瘀汤对子宫腺肌症患者临床疗效及炎症因子的影响。方法:选择符合气滞血瘀型子宫腺肌症患者121例,随机分为观察组62例和对照组59例。对照组疼痛开始时口服芬必得胶囊,疼痛消失时停止服用;观察组内服中药活血逐瘀汤,每个周期服用10天;均连续服用3个月经周期。观察2组的临床疗效;记录并比较2组治疗前后疼痛程度评分、症候积分;检测并比较2组血清炎症因子水平;观察有无不良反应。结果:观察组总有效率为72.58%,高于对照组42.37%,差异有统计学意义(P<0.05)。治疗后,2组中医证候评分及VAS评分较治疗前降低,观察组中医证候评分及VAS评分低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组白细胞介素-6(IL-6)、前列腺素E2(PGE2)、前列腺素F2α(PGF2α)水平较治疗前降低,观察组IL-6、PGE2、PGF2α水平低于对照组,差异均有统计学意义(P<0.05)。结论:活血逐瘀汤可显著改善子宫腺肌症患者的临床证候、疼痛症状,降低炎症因子水平,可以有效治疗子宫腺肌症。Objective：To observe the clinical effect of Huoxue Zhuyu tang for adenomyosis and its effect on inflammatory factors.Methods：Selected 121 cases of patients with adenomyosis of qi stagnation and blood stasis type and divided them into the observation group and the control group randomly,respectively 62 cases and 59 cases in each group.The control group received oral administration of ibuprofen sustained release capsules for treatment when pain began and stopped taking when pain disappeared.The observation group received Chinese medicine of Huoxue Zhuyu tang for ten days as a course every menstrual cycle.Both groups continuously received treatment for three menstrual cycles.Observed the clinical effect in both groups.Recorded and compared scores of pain degree and symptoms in both groups before and after treatment.Detected and compared levels of serum inflammatory factors in both groups.Observed whether there were adverse reactions in both groups.Results：The total effective rate was 72.58% in the observation group,higher than that in the control group,which was 42.37%,the difference being significant（P 0.05）.After treatment,Chinese medicine syndrome scores and VAS scores in both groups were decreased when compared with those before treatment,while Chinese medicine syndrome scores and VAS scores in the observation group were lower than those in the control group,differences being significant（P 0.05）.After treatment,Levels of IL-6,PGE2 and PGF2α in both groups were decreased when compared with those before treatment,while levels of IL-6,PGE2 and PGF2α in the observation group were lower than those in the control group,differences being significant（P 0.05）.Conclusion：Huoxue Zhuyu tang can remarkably improve clinical symptoms and pain degree,decrease levels of inflammatory factors and effectively in treating adenomyosis.

关 键 词：子宫腺肌症 活血逐瘀汤 疼痛评分 中医症候积分 炎症因子 临床疗效 

分 类 号：R711.7[医药卫生—妇产科学]