中老年人群血尿酸水平与颈动脉粥样硬化的相关性  

ASSOCIATION BETWEEN CAROTID ATHEROSCLEROSIS AND SERUM URIC ACID LEVEL IN MIDDLE-AGED AND ELDERLY PEOPLE

作　　者：张冉冉 李慧[1] 王霞霞[1] 李姗[1] 于玲范[1] ZHANG Ranran;LI Hui;WANG Xiaxia;LI Shan;YU Lingfan(Department of Cardiovascular Medicine, The Affiliated Hospital of Qingdao University, Qingdao 266003, Chin)

机构地区：[1]青岛大学附属医院心内科,山东青岛266003

出　　处：《青岛大学医学院学报》2017年第5期589-592,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨中老年人群血尿酸(SUA)水平与颈动脉粥样硬化的相关性。方法选取2016年1月—2017年2月在青岛大学附属医院健康体检中心查体的40~75岁的体检者334例,根据SUA水平分为高尿酸血症组和非高尿酸血症组。记录体检者的年龄、性别、SUA、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)、空腹血糖(FPG)水平以及颈动脉内中膜厚度(CIMT)。比较两组上述指标的差异,并对所有研究对象SUA水平与颈动脉粥样硬化的相关性进行分析。结果高尿酸血症组病人的CIMT显著高于非高尿酸血症组(t=2.206,P<0.05)。所有研究对象的SUA水平与年龄呈负相关(r=-0.226,P<0.05),与TG、LDL、TC、FPG呈正相关(r=0.175~0.426,P<0.05)。多因素Logistic回归分析显示,SUA水平与是否存在颈动脉粥样硬化斑块有关联(OR=1.003,95%CI=1.001~1.006,P<0.01)。结论高尿酸血症是颈动脉粥样硬化的高危致病因素之一。Objective To investigate the association between carotid atherosclerosis and serum uric acid（SUA）level in middle-aged and elderly people.Methods A total of 334 people aged 40-75 years who underwent physical examination in the Physical Examination Center of The Affiliated Hospital of Qingdao University from January 2016 to February 2017 were divided into two groups based on the SUA level：hyperuricemia group and non-hyperuricemia group.The following indices were compared between the two groups：age,sex,SUA level,levels of triglyceride（TG）,total cholesterol（TC）,high-density lipoprotein（HDL）,low-density lipoprotein（LDL）,and fasting plasma glucose（FPG）,and carotid intima-media thickness（CIMT）.The association between carotid atherosclerosis and SUA level was analyzed in all subjects.Results The hyperuricemia group had a significantly higher CIMT than the non-hyperuricemia group（t=2.206,P〈0.05）.In all subjects,the SUA level was negatively correlated with age（r=-0.226,P〈0.05）and positively correlated with levels of TG,LDL,TC,and FPG（r=0.175-0.426,P〈0.05）.The multivariate logistic regression analysis showed that the presence of carotid atherosclerotic plaque was associated with high SUA level（OR=1.003,95%CI=1.001-1.006,P〈0.01）.Conclusion Hyperuricemia is a high-risk pathogenic factor for carotid atherosclerosis in middle-aged and elderly people.

关 键 词：颈动脉 动脉粥样硬化 高尿酸血症 颈动脉内膜中膜厚度 中年人 老年人 

分 类 号：R543.4[医药卫生—心血管疾病]