清热宣肺方治疗小儿病毒性肺炎痰热闭肺证  

Treatment of phlegm and heat blocking lung syndrome in children with viral pneumonia by Qingre Xuanfei decoction

作　　者：王春荣[1] 朱慧华[2] WANG Chunrong;ZHU Huihua(Shanghai Jiading Hospital of Traditional Chinese Medicine, Shanghai 201800, China;Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China)

机构地区：[1]上海市嘉定区中医医院,上海201800 [2]上海中医药大学附属岳阳中西医结合医院,上海200437

出　　处：《长春中医药大学学报》2018年第2期342-345,共4页Journal of Changchun University of Chinese Medicine

基　　金：上海海派中医流派传承研究基地项目(ZYSNXD-CC-HPGC-JD-005)

摘　　要：目的观察清热宣肺方治疗小儿病毒性肺炎痰热闭肺证的临床疗效。方法收纳符合标准的84例病毒性肺炎痰热闭肺证患儿,采用随机对照的设计方法,将患儿分为治疗组和对照组,治疗组39例用利巴韦林注射液静脉滴注加清热宣肺方口服,对照组45例用利巴韦林注射液静脉滴注加易坦静口服。观察治疗前后患儿的症状、体征及外周血T淋巴细胞亚群的变化。结果治疗组在改善相关症状体征如痰壅、咳嗽、肺部听诊方面优于对照组(P<0.05)。胸部正位X线片方面改善优于对照组(P<0.05)。治疗组能改善因病毒感染而下降的CD_4^+、CD_4^+/CD_8^+水平及因病毒感染而上升的CD_8^+水平,优于对照组(P<0.05)。治疗组在总体疗效方面显著优于对照组(P<0.05)。结论清热宣肺方是一种治疗小儿病毒性肺炎痰热闭肺证的有效药物,可以改善症状体征、缩短病程及减少住院时间。Objective Observe the clinical effect of Qingre Xuanfei decoction in treating the syndrome of phlegm and heat obstructing the pulmonary of childhood viral pneumonia.Methods This study received 84 patients with syndrome of phlegm heat obstructing the lung of childhood viral pneumonia,randomized controlled design method.The patients were divided into treatment group and control group.Treatment group（39 cases）applying ribavirin injection plus Qingre Xuanfei decoction,45 cases were applied ribavirin injection plus ambrocol oral solution.To observe the patient＇s symptoms,signs and changes of T lymphocyte subsets in peripheral blood,using the statistical analysis SPSS15 software.Results The treatment group was better than the control group in improving symptoms and signs such as phlegm,cough,lung auscultation.The treatment group was better than the control group in improving chest X-ray.The treatment group can improve the level of CD4~＋,CD4~＋/CD8~＋ and the level of CD8~＋ increased due to viral infection,which is better than that of the control group.the treatment group was superior to the control group in overall efficacy.Conclusion Qingre Xuanfei decoction is an effective compound for syndrome of phlegm heat obstructing the lung of childhood viral pneumonia.It can improve the symptoms and signs,shorten the course of disease and reduce the length of hospital stay,which is worthy of clinical application.

关 键 词：清热宣肺方 病毒性肺炎 痰热闭肺证 外周血T淋巴细胞亚群 

分 类 号：R272.6[医药卫生—中医儿科学]