小剂量茶碱对稳定期老年COPD患者免疫功能及血清炎性因子的影响  

Effects of low-dose theophylline on immune function and serum inflammatory factors in stable elderly COPD patients

作　　者：唐秋静[1] 陈森[1] 许伟珍 杨广权 TANG Qiu-jing;CHEN Sen;XU Wei-zhen;et al.(Department Six of Internal Medicine, Guangdong Agribusiness Central Hospital, Zhanjiang 524200, Chin)

机构地区：[1]广东省农垦中心医院内六科,524200

出　　处：《中国实用医药》2018年第11期83-85,共3页China Practical Medicine

摘　　要：目的分析小剂量茶碱应用于稳定期老年慢性阻塞性肺疾病(COPD)患者对其血清炎性因子和免疫功能的影响。方法 82例稳定期老年COPD患者,采用随机数字表法分为对照组(40例)和研究组(42例)。对照组给予常规治疗,研究组在常规治疗基础上给予小剂量茶碱治疗,观察两组患者治疗前后免疫功能(指标包括CD4+、CD8+及CD4+/CD8+)和血清炎性因子[白细胞介素(IL)-6、IL-8、IL-17、C反应蛋白(CRP)以及肿瘤坏死因子(TNF)-α]改善情况。结果治疗前,两组CD4+、CD8+及CD4+/CD8+水平比较,差异无统计学意义(P>0.05)。治疗后,研究组的CD4+、CD8+和CD4+/CD8+水平与对照组比较,差异均有统计学意义(P<0.05)。治疗前,两组IL-6、IL-8、IL-17、CRP及TNF-α水平比较,差异无统计学意义(P>0.05)。治疗后,研究组IL-6(8.2±1.3)pg/ml、IL-8(9.3±1.5)pg/ml、IL-17(4.3±0.6)pg/ml、CRP(5.1±0.4)mg/L及TNF-α(42.5±3.6)pg/ml均低于对照组的(10.7±1.9)pg/ml、(12.4±2.2)pg/ml、(6.2±1.1)pg/ml、(7.2±0.9)mg/L、(51.6±4.7)pg/ml,差异有统计学意义(P<0.05)。结论在对稳定期老年COPD患者进行治疗时使用小剂量茶碱辅助治疗,可有效改善患者机体免疫功能,降低患者炎性指标,从而促进患者恢复,可推广应用。Objective To analyze the effect of low-dose theophylline on immune function and serum inflammatory factors in stable elderly chronic obstructive pulmonary disease（COPD）patients.Methods A total of 82 stable elderly COPD patients were divided by random number table method into control group（40 cases）and research group（42 cases）.The control group received conventional therapy,and the research group received low-dose theophylline for treatment on the basis of conventional therapy.The improvement of immune function（including CD4＋,CD8＋ and CD4＋/CD8＋）and serum inflammatory factors[interleukin（IL）-6,IL-8,IL-17,C reactive protein（CRP）and tumor necrosis factor-α（TNF）-α]between the two groups before and after treatment were observed.Results Before treatment,both groups had no statistically significant difference in CD4＋,CD8＋ and CD4＋/CD8＋ level（P〉0.05）.After treatment,the research group had statistically significant difference in CD4＋,CD8＋ and CD4＋/CD8＋ level,comparing with the control group（P〈0.05）.Before treatment,both groups had no statistically significant difference in IL-6,IL-8,IL-17,CRP and TNF-α level（P〉0.05）.After treatment,the research group had lower IL-6 as（8.2±1.3）pg/ml,IL-8 as（9.3±1.5）pg/ml,IL-17 as（4.3±0.6）pg/ml,CRP as（5.1±0.4）mg/L and TNF-α as（42.5±3.6）pg/ml than（10.7±1.9）pg/ml,（12.4±2.2）pg/ml,（6.2±1.1）pg/ml,（7.2±0.9）mg/L and（51.6±4.7）pg/ml in the control group,and their difference was statistically significant（P〈0.05）.Conclusion During the treatment of stable elderly COPD patients,application of low-dose theophylline adjuvant therapy can effectively improve the immune function of patients,reduce their inflammatory index,thereby promoting the recovery of patients,and it can be widely promoted and applied.

关 键 词：小剂量茶碱 免疫功能 慢性阻塞性肺疾病 血清炎性因子 

分 类 号：R563.9[医药卫生—呼吸系统]