Synthesis,characterization and cell imaging properties of rare earth compounds based on hydroxamate ligand  

作　　者：Linyan Yang Yanping Zhang Liwei Hu Yunhe Zong Ruili Zhao Tianming Jin Wen Gu 

机构地区：[1]College of Animal Science and Veterinary Medicine,Tianjin Agricultural University,Tianjin 300384,China [2]Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources,Guangxi Normal University,Guilin 541004,China [3]College of Chemistry,Collaborative Innovation Center of Chemical Science and Engineering(Tianjin),Nankai University,Tianjin 300071,China [4]Key Laboratory of Advanced Energy Materials Chemistry(KLAEMC),Nankai University,Tianjin 300071,China

出　　处：《Journal of Rare Earths》2018年第4期418-423,共6页稀土学报（英文版）

基　　金：Project supported by State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Guangxi Normal University)(CMEMR2016-B12);the National Natural Science Foundation of China(31572492,21401031,21371103,31372482);the Innovative and Entrepreneurial Training Plan for Tianjin College Students(201710061035);the Natural Science Foundation of Tianjin(12JCZDJC22100);the General Fund of Application Foundation and Advanced Technology Program of Tianjin(14JCYBJC30000);the Veterinary Biotechnology Scientific Research Innovation Team of Tianjin,China(TD12-5019)

摘　　要：Six binuclear rare earth compounds were synthesized through the ligand of 4-Bromo-N-hydroxy-Nmethyl-benzamide（sH_2 bha）. Compounds 1-3 are isomorphous, and compound 1 is crystallized in the monoclinic system with the P2_1/c space group. Compounds 4 and 5 are isomorphous, and compound 4 is crystallized in the triclinic system with the P-1 space group. Compound 6 is crystallized in the triclinic system with the P-1 space group. The compounds were characterized by thermogravimetric analysis（TGA） and IR spectroscopy. The fluorescence spectrum in the visible area shows characteristic peaks of Eu, Tb, and Dy compounds. The efficiency of Eu compound on the viability of PC3 cells was assessed using CCK8 assays. From the CCK8 results, ionic concentration may have a great effect on PC3 cells＇ proliferation. Eu compound shows red fluorescence in the cytoplasm of PC3 cell. As for Eu compound, it might have potential application in cell imaging technology.Six binuclear rare earth compounds were synthesized through the ligand of 4-Bromo-N-hydroxy-Nmethyl-benzamide（sH_2 bha）. Compounds 1-3 are isomorphous, and compound 1 is crystallized in the monoclinic system with the P2_1/c space group. Compounds 4 and 5 are isomorphous, and compound 4 is crystallized in the triclinic system with the P-1 space group. Compound 6 is crystallized in the triclinic system with the P-1 space group. The compounds were characterized by thermogravimetric analysis（TGA） and IR spectroscopy. The fluorescence spectrum in the visible area shows characteristic peaks of Eu, Tb, and Dy compounds. The efficiency of Eu compound on the viability of PC3 cells was assessed using CCK8 assays. From the CCK8 results, ionic concentration may have a great effect on PC3 cells＇ proliferation. Eu compound shows red fluorescence in the cytoplasm of PC3 cell. As for Eu compound, it might have potential application in cell imaging technology.

关 键 词：Rare earth Fluorescence Cell imaging 

分 类 号：O641.4[理学—物理化学]