利拉鲁肽治疗2型糖尿病合并多囊卵巢综合征的临床效果观察  

Clinical effect of liraglutide on type 2 diabetes mellitus complicated with polycystic ovary syndrome

作　　者：李秋云[1] 刘星[1] 李昊轩 杨春伟[1] 张卫欢[1] 王婷婷 郭智慧 周艳茹 Li Qiuyun;Liu Xing;Li Haoxuan;Yang Chunwei;Zhang Weihuan;Wang Tingting;Guo Zhihui;Zhou Yanru(Department of Endocrinology, Kailuan General Hospital, Hebei Province, Tangshan 063000, China;Department of Clinical Medicine, Sohthern Medical University, Guangzhou 510515, China)

机构地区：[1]开滦总医院内分泌科,河北省唐山市063000 [2]南方医科大学临床医学系,广州510515

出　　处：《中国医药》2018年第4期549-552,共4页China Medicine

摘　　要：目的探讨利拉鲁肽对2型糖尿病合并多囊卵巢综合征患者的临床疗效。方法选取2015年1月至2016年12月于开滦总医院就诊的2型糖尿病合并多囊卵巢综合征患者60例,应用随机数字表分为2组,各30例。对照组采取饮食运动干预方法,观察组在对照组基础上联合利拉鲁肽治疗,24周为1个疗程,比较2组患者治疗前后的腰围、体重指数、空腹血糖、糖化血红蛋白和血脂,并行彩色多普勒超声检查测量成熟卵泡直径。结果治疗前2组患者的年龄、腰围、体重指数、空腹血糖、糖化血红蛋白和血脂以及成熟卵泡直径比较差异均无统计学意义(均P>0.05)。治疗后,对照组空腹血糖、糖化血红蛋白、体重指数、腰围均低于治疗前,成熟卵泡直径大于治疗前(均P<0.05);观察组低密度脂蛋白胆固醇、三酰甘油、总胆固醇、空腹血糖、糖化血红蛋白、体重指数、腰围均低于治疗前,高密度脂蛋白胆固醇高于、成熟卵泡直径大于治疗前(均P<0.05);且观察组治疗后总胆固醇、空腹血糖、糖化血红蛋白均低于对照组[(5.4±0.8)mmol/L比(5.8±0.8)mmol/L、(6.6±0.5)mmol/L比(7.7±0.8)mmol/L、(5.2±0.4)%比(5.8±1.O)%],高密度脂蛋白胆固醇高于、成熟卵泡直径大于对照组[(1.43±0.22)mmol/L比(1.25±0.27)mmol/L、(1.10±0.10)cm比(0.83±0.11)cm],差异均有统计学意义(均P<0.05)。结论利拉鲁肽治疗2型糖尿病合并多囊卵巢综合征可明显降低患者的空腹血糖、糖化血红蛋白和总胆固醇,并促进卵泡发育。Objective To explore the clinical effect of liraglutide on type 2 diabetes mellitus complicated with polycystic ovary syndrome. Methods Sixty type 2 diabetic patients with polycystic ovary syndrome who visited Kailuan General Hospital from January 2015 to December 2016 were randomly divided into control group and observation group, with 30 cases in each group. The control group had diet and exercise intervention; the observation group was treated by liraglutide for 24 weeks. Waist circumference, body mass index, fasting blood glucose, glycosylated hemoglobin and blood lipid were analyzed before and after treatment. Diameter of mature follicle was measured by color Doppler ultrasound. Results There were no significant differences of age, waist circumference, body mass index, fasting blood glucose, glycosylated hemoglobin, blood lipid and mature follicle diameter between groups before treatment （ P 〉 0.05 ）. After treatment, fasting blood glucose, glycosylated hemoglobin, body mass index, waist circumference in control group were significantly lower and mature follicle diameter was significantly higher than those before treatment （ P 〈 0. 05 ） ; low-density lipoprotein cholesterol, triacylglycerol, total cholesterol, fasting blood glucose, glycosylated hemoglobin, body mass index, waist circumference in observation group were significantly lower and high-density lipoprotein cholesterol, mature follicle diameter were significantly higher than those before treatment（P 〈0.05 ）. Total cholesterol, fasting blood glucose and glycosylated hemoglobin after treatment in observation group were significantly lower than those in control group [ （5.4 ±0. 8） mmol/L vs （5.8 ±0. 8） mmol/L, （6. 6 ±0. 5） mmol/L vs （7.7±0. 8） mmol/L, （5.2 ±0. 4）% vs （ 5.8 ±1.0 ） % ] ; high-density lipoprotein cholesterol and mature follicle diameter after treatment in observation group were significantly higher than those in control group [ （ 1.43±0. 22 ） mmol/L vs （ 1.25 ± 0. 27 ） mmol/L, （

关 键 词：糖尿病 2型 利拉鲁肽 多囊卵巢综合征 

分 类 号：R587.1[医药卫生—内分泌]