三乙胺催化的α-硝基乙酸酯与α,β-不饱和酰基吡唑的Michael加成反应  

Michael Addition of α-Nitroacetate to α,β-Unsaturated Pyrazolamide Catalyzed by Triethylamine

作　　者：刘莹莹 何谦 陈峰[1] 李雪锋[1] Liu Yingying, He Qian, Chen Feng, Li Xuefeng(School of Chemistry and Environmental Protection Engineering, Southwest Minzu University, Chengdu 610041, Chin)

机构地区：[1]西南民族大学化学与环境保护工程学院,四川成都610041

出　　处：《山东化工》2018年第8期4-8,共5页Shandong Chemical Industry

基　　金：西南民族大学研究生创新型科研项目(CX2016SZ060);西南民族大学2017年省级大学生创新创业训练计划项目(S201710656027)

摘　　要：在三乙胺的催化下,α-硝基乙酸酯顺利与α,β-不饱和酰基吡唑发生Michael加成反应,以50%~88%的产率得到加成产物。反应表现出较好的底物适应性,各种电子性质以及大位阻的α,β-不饱和酰基吡唑都能够顺利发生加成反应。所有的产物结构都经~1H-NMR、^(13)C-NMR和HRMS确认。加成产物能够在温和的条件下转化为相应的功能分子。An efficient Michael addition of α-nitroacetate to α,β-unsaturated pyrazolamide was developed in the presence of triethylamine. Synthetically useful yields（ 50% ～ 88%） have been achieved with various α,β-unsaturated pyrazolamides. The structures of adducts have been clearly confirmed by ^1H-NMR,^（13）C-NMR and HRMS analysis. Adducts resulting from this protocol are useful synthetic intermediates for further synthetic modification.

关 键 词：MICHAEL加成 α-硝基乙酸酯 α β-不饱和酰基吡唑 三乙胺 

分 类 号：O621.25[理学—有机化学]