苦参素胶囊对慢性乙型肝炎患者HBeAg和HBV DNA阴转率作用的Meta分析  

Meta analysis of the effect of marine capsules on the negative conversion rates of HBeAg and HBV DNA in patients with chronic hepatitis B

作　　者：郑洋 赵铁建 ZHENG Yang;ZHAO Tie-jian(School of Basic Medicine, Guangxi University of Traditional ChineseMedicine, Nanning 530000, China;Department of Physiology, School of Basic Medicine, GuangxiUniversity of Traditional Chinese Medicine, Nanning 530000, China)

机构地区：[1]广西中医药大学基础医学院,南宁530000 [2]广西中医药大学基础医学院生理教研室,南宁530000

出　　处：《中国肝脏病杂志（电子版）》2018年第1期18-22,共5页Chinese Journal of Liver Diseases：Electronic Version

基　　金：国家自然科学基金项目(81460682;81660705);广西中医药大学校级重点硕士研究生创新项目(YCSZ2018013)

摘　　要：目的分析苦参素胶囊对慢性乙型肝炎(chronic hepatitis B,CHB)患者HBe Ag和HBV DNA阴转率的影响。方法以苦参素胶囊、氧化苦参碱、慢性乙型肝炎和marine capsules为检索词,检索自建库到2017年8月中国知网、万方数据、重庆维普、PubMed和Embase数据库中苦参素胶囊治疗CHB的随机对照试验。采用Jadad量表对文献质量进行评估,采用RevMan 5.3软件进行Meta分析。结果共纳入13篇文献,总计1523例患者,治疗组1048例,对照组475例,经过Meta分析得出,苦参素胶囊可提高CHB患者HBeAg和HBV DNA的阴转率,减少病毒复制,差异有统计学意义(P<0.05)。结论苦参素胶囊可显著提高CHB患者HBeAg和HBV DNA的阴转率且不良反应轻微。Objective To analyze the effect of the marine capsule on the negative conversion rates of HBeAgand HBV DNA in patients with chronic hepatitis B （CHB）. Methods Randomized and controlled trials on thetreatment of CHB with matrine capsule in CNKI, Wanfang Data, Chongqing Weipu, PubMed and Embasedatabase from database construction to August 2017 were retrieved with the key words matrine capsule,oxymatrine, chronic hepatitis, marine capsules, etc. The literature were evaluated by Jadad scale, and Metaanalysis was operated by RevMan5.3. Results A total of 13 studies and 1523 patients （1048 patients intreatment group and 475 patients in control group） were included. Marine capsules could greatly improvethe negative conversion rates of HBeAg and HBV DNA and could reduce virus replication according to theresults of Meta analysis （P 〈 0.05）. Conclusion Marine capsules can significantly increase the negativeconversion rates of HBeAg and HBV DNA in patients with CHB, with little adverse effects.

关 键 词：苦参素胶囊 HBeAg阴转率 HBVDNA阴转率 META分析 

分 类 号：R512.62[医药卫生—内科学]