丙型肝炎患者血清HCV载量与肾功能损伤程度的关系  

Correlation between kidney injury and viral load in patients with hepatitis C

作　　者：李海东[1] 李连友[1] 孙丽红 尚明全[1] 柏立欣[1] LI Hai-dong;LI Lian-you;SUN Li-hong;SHANG Ming-quan;BAI Li-xin(Department of Laboratory,Chifeng Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China;Department of Laboratory,Affiliated Hospital of Chifeng University, Chifeng 024005, Inner Mongolia Autonomous Region, China)

机构地区：[1]赤峰市医院检验科,内蒙古自治区赤峰024000 [2]赤峰学院附属医院检验科,内蒙古自治区赤峰024005

出　　处：《中国肝脏病杂志（电子版）》2018年第1期35-39,共5页Chinese Journal of Liver Diseases：Electronic Version

摘　　要：目的探讨丙型肝炎患者血清HCV载量与肾功能损伤程度的关系。方法随机选取2016年6月至2016年12月于赤峰市医院就诊的203例HCV感染者及57例健康对照为研究对象,分别检测血清HCV RNA载量、BUN、Cr、UA及Cys C水平,分析HCV载量与肾功能损伤的相关性。结果 HCV感染组患者血清BUN及Cys C水平均显著高于健康对照组,差异有统计学意义(t值分别为4.022、6.555,P均<0.001),血清Cr及UA差异无统计学意义(t值分别为1.535、0.071,P值分别为0.546、0.837)。HCV感染者的病毒载量与血清Cys C呈显著负相关(r=-0.232,P=0.009)。结论 Cys C可能与控制HCV的复制有关,联合检测血清BUN、Cr及Cys C水平可更好地评估HCV感染者的肾功能损伤。Objective To investigate the correlation between kidney injury and viral load in patients withhepatitis C. Methods Total of 203 patients with HCV infection and 57 healthy controls in Chifeng Hospitalfrom June 2016 to December 2016 were randomly selected. The levels of serum urea nitrogen, creatinine（Cr）, uric acid （UA）, cystatin C （CysC） and HCV RNA load were detected. Results The levels of serumurea nitrogen and cystatin C in patients with HCV infection were higher than those of healthy controls, thedifferences were statistically significant （t = 4.022, 6.555; P 〈 0.001）. There was no significant differencebetween serum Cr and UA （t = 1.535, 0.071; P = 0.546, 0.837）. There was a significant negative correlationbetween CysC levels and HCV RNA load in patients with HCV infection （r = -0.232, P = 0.009）. ConclusionsCysC may be associated with HCV replication, combined detection of BUN, Cr and CysC can better evaluaterenal function injury in patients with HCV infection.

关 键 词：肝炎病毒 丙型 尿素氮 胱抑素C 

分 类 号：R446.1[医药卫生—诊断学] R512.63[医药卫生—临床医学]