两种氨氯地平贝那普利片治疗原发性高血压的对比研究  

Comparative Study of Two Amlodipine Benazepril Tablets in the Treatment of Essential Hypertension

作　　者：杨德志[1] 吴燕[1] 韩辉[1] YANG Dezhi;WU Yan;HAN Hui(Department of Cardiology, Hechi City People＇s Hospital, Hechi Guangxi 547000, Chin)

机构地区：[1]广西壮族自治区河池市人民医院心血管内科,广西河池547000

出　　处：《中国继续医学教育》2018年第14期151-153,共3页China Continuing Medical Education

摘　　要：目的对比两种不同剂型的氨氯地平贝那普利片治疗原发性高血压的临床疗效和安全性。方法 175例轻中度原发性高血压患者随机分为两组:Ⅰ型组患者给予氨氯地平贝那普利片Ⅰ(2.5 mg/10 mg)1片,每日1次,疗程8周;Ⅱ型组给予氨氯地平贝那普利片Ⅱ(5 mg/10mg)1片,每日1次,疗程8周;评估两组患者的SBP和DBP的下降程度、总体有效率以及不良反应。结果Ⅱ型组SBP和DBP下降幅度显著高于Ⅰ型组(P<0.05);两组降压的有效率分别为73.25%(Ⅰ型组)和85.39%(Ⅱ型组),Ⅱ型组总有效率高于Ⅰ型组(P<0.05);两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论氨氯地平贝那普利片Ⅱ(5 mg/10 mg)治疗原发性高血压疗效优于氨氯地平贝那普利片Ⅰ(2.5 mg/10 mg),两种药物均安全、有效,且无严重不良反应。Objective To compare the clinical efficacy and safety of two different formulations of Amlodipine Besylate and Benazepril Hydrochloride Tablets in the treatment of essential hypertension. Methods A total of 175 patients with essential hypertension were randomly divided into two groups patients in groups I were treated with amlodipine benazepril 2.5 mg /10 mg, once a day, for 8 weeks.Patients in group II were treated with amlodipine benazepril 5 mg /10 mg, once a day, for 8 weeks. The degree of decline in SBP and DBP, overall efciency and adverse reactions were assessed in the two groups. Results The decrease of SBP and DBP in group II was significantly higher than that in group I （P 〈 0.05）. The effective rates of the two groups were 73.25% （group I） and 85.39% （group II）, respectively. The total efective rate of group II was higher than that in I group （P 〈 0.05）. There was no signifcant diference in the incidence of adverse reactions between the two groups （P 〉 0.05）. Conclusion Our study indicated that amlodipine benazepril 5 mg/10mg ofered signifcant additional BP reductions and BP control rate compared with the amlodipine benazepril 2.5 mg/10 mg. No signifcant diferences were observed in side efect between two drugs.

关 键 词：氨氯地平贝那普利片 高血压 临床疗效 安全性 

分 类 号：R453[医药卫生—治疗学]