二丁酰环磷腺苷钙联合丹参多酚酸盐在急性心肌梗死中的临床应用价值  

Clinical application value of Calcium Dibutyryladenosine Cyclophosphate combined with Salvianolate in acute myocardial infarction

作　　者：倪伟欣 吴强[1] 王楚林[1] 林宇鹏[1] 张华弟[1] NI Wei-xin;WU Qiang;WANG Chu-lin;LIN Yu-peng;ZHANG Hua-di(First Department of Cardiovascular Medicine,the People＇s Hospital in Jieyang City,Guangdong Province Jieyang 522000, Chin)

机构地区：[1]广东省揭阳市人民医院心血管内一科,广东揭阳522000

出　　处：《中国当代医药》2018年第11期121-123,共3页China Modern Medicine

摘　　要：目的探索、分析二丁酰环磷腺苷钙联合丹参多酚酸盐在急性心肌梗死中的临床效果。方法选取2016年4月~2017年12月我院收治的100例急性心肌梗死患者作为研究对象,根据治疗方法将其分为两组,每组各50例。对照组患者采用常规治疗,观察组患者采用二丁酰环磷腺苷钙联合丹参多酚酸盐治疗。比较两组患者的心功能指标水平、GRACE冠心病风险评分、NIHSS心功能等级、不良事件发生率。结果观察组患者的不良事件总发生率(2.00%)低于对照组(24.00%),差异有统计学意义(P<0.05)。治疗后,观察组NYHA心功能等级的Ⅰ、Ⅱ级患者占比明显高于对照组,Ⅲ、Ⅳ级患者占比低于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组患者的LVEDD[(48.51±2.37)mm]、LVESD[(30.53±1.74)mm]低于对照组[(55.46±1.61)、(42.94±1.52)mm],LVEF[(56.52±5.74)%]高于对照组[(43.37±1.26)%],差异均有统计学意义(P<0.05)。治疗后,观察组患者的GRACE冠心病风险评分为(70.65±6.11)分,低于对照组的(76.52±7.52)分,差异有统计学意义(P<0.05)。结论对急性心肌梗死患者实施二丁酰环磷腺苷钙联合丹参多酚酸盐治疗,效果显著,且治疗安全性较高。Objective To explore and analyze the clinical effect of Calcium Dibutyryladenosine Cyclophosphate combined with Salvianolate in acute myocardial infarction.Methods A total of 100 patients with acute myocardial infarction in our hospital from April 2016 to December 2017 were selected as experimental subjects and divided into two groups according to the treatment methods,50 cases in each group.The patients in the control group were treated with conventional treatment,and the patients in the observation group were treated with Calcium Dibutyryladenosine Cyclophosphate combined with Salvianolate.The heart function index level,GRACE coronary heart disease risk score,NIHSS heart function level and adverse event incidence were compared between the two groups.Results The total incidence of adverse events in the observation group（2.00%） was lower than that in the control group（24.00%）,and the difference was statistically significant（P〈0.05）.After treatment,the proportion of NYHA cardiac function grade Ⅰand Ⅱ in the observation group were significantly higher than those in the control group,while the proportion of Ⅲ and Ⅳ grade were lower than those in the control group,and the differences were statistically significant（P〈0.05）.After treatment,the LVEDD（[48.51±2.37] mm）and LVESD（[30.53±1.74] mm） in the observation group were lower than those in the control group（[55.46±1.61],[42.94±1.52] mm）,while the LVEF（[56.52±5.74] %） in the observation group was higher than that in the control group（[43.37±1.26] %）,and the differences were statistically significant（P〈0.05）.After treatment,the GRACE coronary heart disease risk score in the observation group was（70.65±6.11） points,which was lower than that in the control group of（76.52±7.52） points,and the difference was statistically significant（P〈 0.05）.Conclusion The treatment of patients with acute myocardial infarction with Calcium Dibutyryladenosine Cyclophosphate combined Salvianolate is effective and saf

关 键 词：二丁酰环磷腺苷钙 丹参多酚酸盐 急性心肌梗死 

分 类 号：R541[医药卫生—心血管疾病]