醋酸曲普瑞林治疗女性中枢性性早熟的效果与安全性探讨  

Therapeutic effect and safety of Triptorelin Acetate in the treatment of central precocious puberty in women

作　　者：魏苗苗[1] WEI Miao-miao(Department of Pediatries,Huizhou First People＇s Hospital,Guangdong Provinee,Huizhou 516000,China)

机构地区：[1]广东省惠州市第一人民医院儿科,广东惠州516000

出　　处：《中国当代医药》2018年第11期136-138,共3页China Modern Medicine

摘　　要：目的探讨分析醋酸曲普瑞林在治疗女性中枢性性早熟中的临床治疗效果及其安全性。方法选取2014年10月~2016年8月我院病房及门诊诊治的90例中枢性性早熟女童患儿作为研究对象,按照治疗方法的不同,将患儿分成两组,每组各45例。实验组患儿给予醋酸曲普瑞林治疗,1年为1个疗程,对照组患儿不予以药物治疗。1个疗程后,观察记录并计算两组患儿治疗前后的身高、体重、BMI指数及预测身高,测定患儿治疗前后的血清E2、FSH及LH等激素水平,评价其治疗效果。结果 1个疗程后,两组患儿的身高、体重、预测身高、骨龄均明显高于治疗前,差异有统计学意义(P<0.05),实验组患儿的身高、体重及预测身高明显高于对照组,骨龄显著低于对照组,差异有统计学意义(P<0.05)。两组患儿的E2、FSH及LH水平均显著低于治疗前,差异有统计学意义(P<0.05)。实验组患儿的E2、FSH及LH水平明显低于对照组,差异有统计学意义(P<0.05)。实验组患儿的不良反应发生率显著低于对照组,差异有统计学意义(P<0.05)。结论醋酸曲普瑞林治疗女性中枢性性早熟的效果良好,值得临床推广。Objective To explore and analyze the clinical efficacy and safety of Triptorelin Acetate in the treatment of central precocious puberty in women.Methods A total of 90 girls with central precocious puberty treated in our outpatient clinics and inpatient wards from October 2014 to August 2016 were selected as the study subjects.According to different treatment methods,the patients were evenly divided into two groups,45 cases in each group.In experimental group,patients were treated with Triptorelin Acetate,one year was for a course of treatment.In control group,patients were not provided with any intervention.After one course of treatment,the height,weight,body mass index（BMI） and predicted height before and after treatment were observed,recorded and calculated.The hormone levels such as serum estradiol（E2）,follicle stimulating hormone（FSH） and luteinising hormone（LH） before and after therapy were determined in order to evaluate the therapeutic efficacy.Results After one course of treatment,the height,weight,predicted height,bone age of the two groups were significantly higher than before treatment,the differences were statistically significant（P〈 0.05）.The the height,weight and predicted height in the experimental group were much higher than those of the control group,while the bone age of the experimental group were significantly lower compared with those in the control group,the differences were statistically significant（P〈0.05）.The serum levels of E2,FSH and LH after therapy in the two groups were significantly lower than those before treatment with statistical significance（P〈0.05）.The levels of E2,FSH and LH in the experimental group were significantly lower than in the control group,the differences were statistically significant（P〈0.05）.The incidence of adverse reactions in the experimental group was significantly lower than that in the control group,and the difference was statistically significant（P〈0.05）.Conclusion The effect of Triptorelin Acetate in the treatm

关 键 词：醋酸曲普瑞林 中枢性性早熟 女性 临床疗效 

分 类 号：R977.1[医药卫生—药品]