Ⅱa型皮质发育不良相关癫痫患者的7T磁共振白质抑制序列显像研究  

Clinical Application of 7T-MRI and White Matter-suppressed Sequences in Patients with FCD-Ⅱa and Epilepsy

作　　者：崔建飞 孙开宝[3] 丁平 崔志强[4] 袁柳 徐欣[4] 张利为 凌至培[4] 薛蓉 梁树立[2,4] CUI Jian-fei;SUN Kai-bao;DING Ping(Training Base for Graduate,the First Affiliated Hospital of PLA General Hospital,Jinzhou Medical University,Beijing 100048, China)

机构地区：[1]锦州医科大学解放军总医院第一附属医院研究生培养基地,北京100048 [2]解放军总医院第一附属医院神经外科,北京100048 [3]中国科学院生物物理研究所脑与认知科学国家重点实验室,北京100101 [4]中国人民解放军总医院神经外科,北京100853

出　　处：《医学与哲学（B）》2018年第4期49-51,共3页Medicine & Philosophy(B)

基　　金：2018年国家自然科学基金项目(81771388;31730039);2017年癫痫病临床医学研究北京市重点实验室开放课题(2017DXBL01);2015年国家科技部973基础科学重大项目(2015CB351701)

摘　　要：通过7T超高场磁共振(MRI)及其新序列扫描实验,探索对局灶性皮质发育不良(FCD)的诊断价值。前瞻性收集经3T-MRI提示可能FCD的癫痫患者术前评估、手术治疗和术后随访等临床资料,术前均进行7T-MRI常规序列和用于增强组织对比度的白质抑制序列新扫描方法。共收集4例患者。7T-MRI图像呈现高空间分辨率和高组织对比度的特点,白质抑制序列能够选择性压制特定组织信号,增强对FCD的敏感度。白质抑制图像可见局部的低信号和灰质厚度变化。相对于3T-MRI,7T-MRI对3例FCD定性诊断更明确,4例病变范围均显示更清楚。术后病理均为FCDⅡa,术后1年均无癫痫发作。7T-MRI白质抑制序列对于FCD-Ⅱa诊断有应用价值。To explore diagnostic values of 7 T-magnetic resonance imaging（ MRI） and its new scan sequences in patients with focal cortex dysplasia（ FCD） and epilepsy. To prospectively enroll patients with probably FCD imaging on 3 T-MRI and finish 7 T-MRI scan,including white matter-suppressed（ WMS） sequences,and collect their data of preoperative assessments,surgical treatment and postoperative follow-ups. Four cases were enrolled. 7 T-MRI presented high signal to noise ratio and high spatial resolution.WMS can selectively suppress signal of special tissue,and improve finding of FCD. FCD-IIa showed abnormal thickness of grey matter and hypointense on 7 T-MRI-WMS. Compared with 3 T-MRI,7 T-MRI rendered more clear diagnosis of FCD in 3 cases,and clearer boundary of FCD in 4 cases. All patients reached seizure free at 1 year follow-up,and their pathological diagnoses were FCD-Ⅱa. 7 T-MRI-WMS shows value in preoperative diagnosis of FCD-Ⅱa.

关 键 词：癫痫 局灶性皮质发育不良 7T磁共振成像 术前评估 白质抑制序列 

分 类 号：R651.1[医药卫生—外科学] R742.1[医药卫生—临床医学]