保肝降脂汤辅助治疗对非酒精性脂肪肝病患者肝功能、胰岛素敏感性的影响  

Effect of the adjuvant Baogan Jiangzhi decoction therapy on liver function and insulin sensitivity in patients with nonalcoholic fatty liver disease

作　　者：强红梅 唐军伟 赵荣 王明选[2] QIANG Hong-mei;TANG Jun-wei;ZHAO Rong;WANG Ming-xuan(Department of Integrated Chinese and Western Medicine, Nanchong Central Hospital in Sichuan Province, Nanchong, Sichuan Province, 637000, China;Department of Integrated Chinese and Western Medicine, Suining Central Hospital in Sichuan Province, Suining, Sichuan Province, 629000, China)

机构地区：[1]四川省南充市中心医院中西医结合科,四川南充637000 [2]四川省遂宁市中心医院中西医结合科,四川遂宁629000

出　　处：《海南医学院学报》2018年第6期707-710,共4页Journal of Hainan Medical University

基　　金：四川省中医药科学技术研究专项(2016Q088)~~

摘　　要：目的:研究保肝降脂汤辅助治疗对非酒精性脂肪肝病患者肝功能、胰岛素敏感性的影响。方法:选择南充市中心医院及遂宁市中心医院新诊断的非酒精性脂肪肝病患者并随机分为接受保肝降脂汤联合常规西医药物治疗的观察组、接受常规西医药物治疗的对照组。治疗前及治疗后2周,测定血清中肝损伤指标、炎症反应标志物、氧化应激标志物的含量以及外周血中胰岛素信号分子的表达量。结果:两组组内治疗后2周时的血清ALT、AST、γ-GT、TBIL、Chemerin、Wnt5a、β-catenin、MDA、NO含量低于治疗前,血清APN、Ghrelin、T-AOC、SOD含量以及外周血IRS1、IRS2、GLUT4表达量高于治疗前且与对照组比较,观察组治疗后2周时的血清ALT、AST、γ-GT、TBIL、Chemerin、Wnt5a、β-catenin、MDA、NO含量较低,血清APN、Ghrelin、T-AOC、SOD含量以及外周血IRS1、IRS2、GLUT4表达量较高。结论:保肝降脂汤辅助治疗非酒精性脂肪肝病能够减轻肝功能损伤并改善胰岛素敏感性。Objective：To study the effect of the adjuvant Baogan Jiangzhi decoction therapy on liver function and insulin sensitivity in patients with nonalcoholic fatty liver disease.Methods：Patients who were newly diagnosed with nonalcoholic fatty liver disease in Nanchong Central Hospital and Suining Central Hospital between March 2015 and October 2017 were selected and randomly divided into the observation group who accepted Baogan Jiangzhi decoction combined with conventional western medicine treatment and the control group who accepted conventional western medicine treatment.The contents of liver damage indexes,inflammatory response markers and oxidative stress markers in serum as well as the expression of insulin signaling molecules in peripheral blood were measured before treatment and 2 weeks after treatment.Results：ALT,AST,γ-GT,TBIL,Chemerin,Wnt5a,β-catenin,MDA and NO contents in serum of both groups 2 weeks after treatment were significantly lower than those before treatment（P〈0.05）whereas APN,Ghrelin,T-AOC and SOD contents in serum as well as IRS1,IRS2 and GLUT4 expression in peripheral blood were significantly higher than those before treatment（P〈0.05）,and compared with those of control group,ALT,AST,γ-GT,TBIL,Chemerin,Wnt5a,β-catenin,MDA and NO contents in serum of observation group 2 weeks after treatment were lower whereas APN,Ghrelin,T-AOC and SOD contents in serum as well as IRS1,IRS2 and GLUT4 expression in peripheral blood were higher.Conclusion：Adjuvant Baogan Jiangzhi decoction therapy for nonalcoholic fatty liver disease can reduce liver function injury and improve insulin sensitivity.

关 键 词：非酒精性脂肪肝病 保肝降脂汤 胰岛素抵抗 炎症反应 

分 类 号：R575[医药卫生—消化系统]