格雷夫斯病^131碘治疗后Th1 Th2 Th17及调节性T细胞的变化  

Changes of Th1, Th2, Th17 and Treg cells in patients with Graves disease after 131-iodine therapy

作　　者：李丽娟[1] 张少然[2,3] 郝慧琴 郭慧芳[5] Li Li- juan;Zhang Shaoran;Hoo Huiqin;Guo Huifang(Department of Nuclear Medicine ,Shanxi Provincial People ~s Hos- pital, Taiyuan 030012, China)

机构地区：[1]山西省人民医院核医学科,太原030012 [2]山西省医学会 [3]山西省卫生和计划生育委员会 [4]山西省中医药大学 [5]山西省人民医院检验科,太原030012

出　　处：《中国药物与临床》2018年第3期326-328,共3页Chinese Remedies & Clinics

基　　金：山西省卫生和计划生育委员会攻关项目(20120133)

摘　　要：目的研究格雷夫斯病131碘治疗后Th1,Th2,Th17及调节性T细胞(Treg细胞)的变化。方法选取2015年1月至10月进行131碘治疗的格雷夫斯病患者30例,选择同期30名性别、年龄相匹配的健康体检者为健康对照组。流式细胞仪测定健康对照组、格雷夫斯病患者131碘治疗前及治疗后4个月外周血Th1,Th2,Th17及Treg细胞的含量。结果 (1)131碘治疗4个月后患者血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平显著降低(P<0.05),促甲状腺素(TSH)显著升高(P<0.05),甲状腺球蛋白抗体(TGAb)、甲状腺微粒体抗体(TMAb)滴度显著减低(P<0.05)。(2)131碘治疗4个月后患者Th1及Th17细胞显著低于治疗前水平(P<0.05),Th2及Treg细胞与治疗前比较差异无统计学意义(P>0.05)。结论有效的131碘治疗后患者Th1,Th17减低,Th1/Th2及Th17/Treg趋向平衡。Objective To investigate the changes of Th1,Th2,Th17 and Treg cells in the patients with Graves disease after the 131-iodine therapy. Methods Thirty patients with Graves disease, who underwent the 131-iodine therapy between January 2015 and October 2015, were included in the study. A contemporary cohort of 30 age and gender-matched healthy subjects were included in the normal control group. Flow cytometry was used to determine the content of Th1,Th2,Th17 and Treg cells in the peripheral blood of patients with Graves disease at the baseline and at4 months after the treatment. Results（1）At 4 months after the 131-iodine therapy, the serum levels of FT3 and FT4 significantly decreased（P〈0.05）, the level of TSH significantly increased（P〈0.05）, and the titers of thyroid-specific autoantibodies TGAb and TMAb significantly decreased（P〈0.05）.（2）At 4 months after the 131-iodine therapy, the levels of Th1 and Th17 cells were significantly lower than those at the baseline（P〈0.05）, and there were no statistically significant differences in the Th2 and Treg cells compared with those at the baseline（P〉0.05）. Conclusion After effective 131-iodine therapy, the Th1 and Th17 levels decreased, and the Th1/Th2 and Th17/Treg levels tend to be balanced in patients with Graves disease.

关 键 词：格雷夫斯病 T淋巴细胞 辅助诱导 碘治疗 

分 类 号：R581.1[医药卫生—内分泌]