脓毒症相关心肌功能障碍的发病机制  

Pathogenesis of sepsis-induced myocardial dysfunction

作　　者：娄云鹏 林兆奋[1] Lou Yunpeng;Lin Zhaofen(Department of Emergency and Critical Care, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China （Lou YP, Lin ZF;Department of Intensive Care Unit, No.40] Hospital of Chinese People＇s Liberation Army, Qingdao 266071, Shandong, China （Lou YP)

机构地区：[1]第二军医大学长征医院急救科,上海200003 [2]解放军第401医院重症医学科,山东青岛266071

出　　处：《中华危重病急救医学》2018年第4期374-376,共3页Chinese Critical Care Medicine

基　　金：国家自然科学基金项目（81571942）

摘　　要：脓毒症是重症加强治疗病房（ICU）常见疾病，由此导致的多器官功能障碍综合征（MODS）是重度脓毒症患者的主要死因。心血管系统是脓毒症的重要靶器官之一，心功能受损的严重程度与脓毒症患者的临床预后密切相关。研究表明，在脓毒症过程中产生的多种细胞因子会对心肌细胞收缩功能、线粒体功能以及自律性调节产生影响，同时诱导心肌细胞凋亡，从而导致心肌功能障碍。本文通过对脓毒症相关心肌功能障碍（SIMD）的发病机制进行综述，旨在进一步阐明SIMD的发病过程，并为后续相关研究提供理论基础。Sepsis is a common disease in intensive care units （ICU）, and the resulted multi-organ dysfunction syndrome （MODS） is the main cause of death in patients with severe sepsis. The cardiovascular system is one of the most important target organ for sepsis. The severity of cardiac dysfunction is closely related to the clinical prognosis of patients with sepsis. Studies have reported that various cytokines are expressed during sepsis. They have influence on myocardial contractile function, mitochondrial function and self-regulation. Where after, it will induce cardiomyocyte apoptosis, which can lead to myocardial dysfunction. In this article, the pathogenesis of sepsis-induced myocardial dysfunction （S1MD） were reviewed to further clarify the pathogenesis of SIMD, and provide theoretical basis for subsequent research.

关 键 词：脓毒症 心肌功能障碍 发病机制 

分 类 号：R459.7[医药卫生—急诊医学]