重度子痫前期并发HELLP综合征影响因素分析  

The risk factors analysis of HELLP syndrome of severe preeclampsia

作　　者：章彩萍[1] 徐秋莲[1] 朱敏[1] ZHANG Cai-ping;XU Qiu-lian;ZHU Min(Obstetrices and Gynecology, Jin Hua Hospital, Jinhua, Zhefiang 321000, China)

机构地区：[1]金华市人民医院产科,浙江金华321000

出　　处：《中华全科医学》2018年第5期795-797,共3页Chinese Journal of General Practice

基　　金：浙江省医药卫生科技计划项目(2013KYD276)

摘　　要：目的探讨重度子痫前期并发HELLP(hemolysis,elevated liver enzymes and low platelet)综合征的影响因素,为预防减少HELLP综合征的发生提供临床资料。方法选取金华市人民医院2007年1月—2017年6月收治的182例重度子痫前期患者,根据术后是否发生HELLP综合征,分为HELLP组及非HELLP组,对可能发生HELLP综合征的相关因素进行分析,并对具有统计学意义的指标,进行多因素Logistic回归分析。结果 182例重度子痫前期患者中发生HELLP综合征者36例,其发生率为19.78%。单因素分析及多因素Logistic回归分析显示:早发型子痫前期(OR=3.533,P=0.012,95%CI:1.421~9.744)、高龄产妇(OR=4.995,P=0.003,95%CI:1.671~10.651)是重度子痫前期并发HELLP综合征发生的独立危险因素。规律产检(OR=0.241,P<0.001,95%CI:0.080~0.721)是重度子痫前期并发HELLP综合征发生的保护因素。结论 HELLP综合征是重度子痫前期的并发症之一,而对高龄产妇及早发型子痫前期患者更应该规律产检,筛查高危因素,以降低HELLP综合征的发生率。Objective To investigate the incidence and risk factors of HELLP syndrome of severe preeclampsia, and pro- vide clinical data for reduce the HELLP syndrome. Methods The clinical data of 182 patients with severe preeclampsia from January, 2007 to January, 2017 in Obstetrices and Gynecology of JiM Hua. The patients were divided into HELLP group and non- HELLP group, according to the HELLP syndrome. The related factors which may be induced HELLP syn- drome were analyzed, and the related factors was analyzed by logistic regression analysis. Results In 182 cases of se- vere preeclampsia patients, including 36 cases of patient with HELLP syndrome, the incidence was 19.78%. Single fac- tor analysis and multi-factor logistic regression analysis shows that the early onset preeclampsia （OR = 3. 533, P = 0.012, 95 % CI： 1.421 - 9. 744）, maternal age （ OR = 4. 995, P = 0. 003, 95 % CI： 1.671 - 10.651 ） was risk factors of se- vere preeclampsia complicated with HELLP syndrome. Regular examination （ OR = 0.241, P 〈 0. 001,95% CI：0. 080 - 0.721 ） was protective factor for severe preeclampsia complicated with HELLP syndrome. Conclusion HELLP syndrome was the complications of and the elderly women with early onset preeclampsia should be regularly examined, screening high-risk factors, in order to reduce the incidence of HELLP syndrome.

关 键 词：重度子痫前期 HELLP综合征 危险因素 

分 类 号：R714.245[医药卫生—妇产科学]