间充质干细胞对巨噬细胞免疫调节效应的研究进展  

Advances in immunomodulatory effect of mesenchymal stem cells on macrophages

作　　者：薛婧 程愈[1] 郝好杰[1] 母义明[1] XUE Jing;CHENG Yu;HAO Haojie;MU Yiming(Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China)

机构地区：[1]解放军总医院内分泌科,北京100853

出　　处：《解放军医学院学报》2018年第4期353-355,359,共4页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金项目(81700680;81700679)~~

摘　　要：间充质干细胞是一类具有自我更新和多向分化潜能的成体干细胞,近年来间充质干细胞强大的免疫调节能力越来越受到重视。巨噬细胞是人体重要的固有免疫细胞,研究发现间充质干细胞能显著调节巨噬细胞的表型和功能,此特性是间充质干细胞抑制炎症和促进组织修复的重要机制之一。本综述主要对间充质干细胞在体内和体外对巨噬细胞功能、表型的调节及其机制进行了分析和总结,为间充质干细胞的临床应用提供新思路。Mesenchymal stem cells are a kind of adult stem cells characterized by the ability to self-renew and differentiate into multiple cell types. Recently, more attention has been paid to the immunomodulation and regenerative capacities of mesenchymal stem cells（MSCs）. Macrophages are essential components of innate immunity. Researches have illustrated that mesenchymal stem cells are able to regulate the phenotype and function of macrophages, and the alteration of macrophages plays a pivotal role in controlling inflammation and facilitating tissue repair. In this review, the mechanism of the regulatory effect of MSCs on macrophages are analyzed and summarized, which may provide a new insight into the clinical application of mesenchymal stem cells.

关 键 词：间充质干细胞 巨噬细胞 免疫调控 

分 类 号：R392[医药卫生—免疫学]