扁平苔藓178例临床分析  

Clinical characteristics of lichen planus in 178 patients

作　　者：李婧[1] 李艳阳[1] 张欣[1] 李铁男[1] LI Jing;LI Yan-yang;ZHANG Xin;LI Tie-nan(Department of Dermatology, the Seventh People＇s Hospital of Shenyang, Shenyang 110003, China)

机构地区：[1]沈阳市第七人民医院皮肤科,辽宁沈阳110003

出　　处：《临床皮肤科杂志》2018年第5期268-272,共5页Journal of Clinical Dermatology

摘　　要：目的 :分析总结扁平苔藓(LP)的发病年龄、临床表现、分型及实验室检查结果。方法 :回顾性分析该院178例LP患者的临床资料。结果:178例LP患者平均发病年龄(46.7±17.1)岁,男女比例1.0∶1.3,50~59岁发病率最高(37.1%)。其中慢性局限性LP(48.3%)最常见,其次为线状LP(16.3%)、急性泛发性LP(5.6%)、光线性LP(5.1%)、大疱性LP(5.1%)、环状LP(4.5%)、色素性LP(3.4%)、口腔LP(2.8%)、毛囊性LP(2.8%)、肥厚性LP(2.2%)、LP-红斑狼疮重叠综合征(2.2%)、类天疱疮样LP(1.1%)及掌跖LP(0.6%)。38例(21.3%)伴口腔受累。所有患者抗核抗体(ANA)阳性率为32.6%,其中LP-红斑狼疮重叠综合征阳性率最高。雷公藤多苷治疗对皮肤型LP有效。结论:LP临床表现差异较大,慢性局限性LP是最常见亚型。LP-红斑狼疮重叠综合征患者ANA阳性率最高,其他亚型与ANA关系有待进一步探讨。Objective： To analyze the epidemiological, clinical and laboratory features of lichen plauus（LP）. Methods： The clin- ical features of LP were retrospectively analyzed in 178 patients. Results： The mean age of onset was 46.7±17.1 years, with a male to female ratio of 1.0：1.3. The highest incidence was found in subjects aged 50 to 59 years o[d（37.1%）. Chronic localized lichen planus was the most common subtype（48.3%）, followed by linear lichen planus（16.3%）, acute generalized lichen planus （5.6%）, lichen planus actinicus（5.1%）, bullous lichen planus（5.1%）, lichen planus annularis（4.5%）, lichen planus pigmentosus （3.4%）, oral lichen planus （2.8%）, follicular lichen planus （2.8% ）, lichen planus hypertrophicus （2.2% ）, overlap syndrome of lichen planus-lupus erythematosus（2.2%）, pemphigoid-like lichen planus（1.1%） and lichen planus of the palms and soles（0.6%）. Involvement of oral mucosa was found in 38 patients. 32.6% of patients displayed anti-nuclear antibody（ANA） positive. Patients with overlap syndrome of lichen planus-lupus erythematosus exhibited the highest positive rates of ANA. Tripterygium glycosides was effective for cutaneous type LP. Conclusions： The clinical manifestations of LP vary greatly, The most common subtype of LP is chronic localized LP. Patients with overlap syndrome of lichen planus-lupus erythematosus display the highest ANA positive rate. Further studies are required to delineate the relationships between other subtypes of LP and ANA.

关 键 词：扁平苔藓 临床分析 

分 类 号：R758.65[医药卫生—皮肤病学与性病学]