SAPHO综合征急性发作  

Acute SAPHO syndrome:a case report

作　　者：范晓晶 孙睿[1] 袁定芬[1] 邓辉[1] FAN Xiao-Jing;SUN Rui;YUAN Ding-Fen;DENG Hui(Department of Dermatalogy, the Sixth People＇s Hospital of Shanghai Affiliated to Shanghai Jiaotong University, Shanghai 200233, Chin)

机构地区：[1]上海交通大学附属第六人民医院皮肤科,上海200233

出　　处：《临床皮肤科杂志》2018年第5期288-290,共3页Journal of Clinical Dermatology

基　　金：国家自然科学基金(81673054)资助项目

摘　　要：报告1例SAPHO综合征急性发作。患者女,28岁。全身泛发脓疱及右侧锁骨剧痛1周。皮肤科检查:病变以手足为主,脓疱形成,部分皮损表面覆有鳞屑,双颊有痤疮表现;右胸锁关节处可触及肿块。全身骨显像示双侧胸锁关节放射性摄取稍增高。皮损组织病理检查:表皮内水疱,真皮乳头状增生伴中性粒细胞浸润,小血管周围炎性细胞浸润。诊断:SAPHO综合征。予口服柳氮磺吡啶和白芍总苷治疗后,病情控制,目前仍在随访中。A case of acute SAPHO syndrome is reported. A 28-year-old woman presented with generalized pustules, and pain on the right clavicle for 1 week. Physical examination showed pustules mainly on the feet and hands. Some lesions were covered with scales. Ache-like lesions presented on both cheeks. A mass could be palpated at the right sternoclavicular joint. Whole body bone imaging showed slightly increased uptake of both sternoclavicular joints. Histopathological examination re- vealed intraepidermal blisters, dermal papillary hyperplasia with neutrophilie infiltration, and perivascular infiltration of inflam- matory cells. The diagnosis of SAPHO syndrome was made. After treatments with sulfasalazine and total glycosides of paeony, disease was controlled and the patient is under follow-up.

关 键 词：SAPHO综合征 急性发作 皮肤病 骨关节病 

分 类 号：R751[医药卫生—皮肤病学与性病学]