水通道蛋白3在银屑病皮损中的表达及意义  

Expression of AQP3 in psoriatic lesions and its significance

作　　者：唐桦[1] 冯浩[1] 廖阳英[1] 李蓝[1] 肖伟荣[1] TANG Hua;FENG Hao;LIAO Yangying;LI Lan;XIAO Weirong(Hunan Provincial People＇s Hospital, Changsha 410005, China)

机构地区：[1]湖南省人民医院,湖南长沙410005

出　　处：《临床医药实践》2018年第4期259-261,共3页Proceeding of Clinical Medicine

摘　　要：目的:探讨水通道蛋白3(AQP3)mRNA在寻常型银屑病皮损中的表达及意义。方法:选取18例寻常型银屑病患者(寻常型银屑病组),取材部位为非曝光部位典型银屑病皮损处;另外选择18例整形外科手术患者(正常对照组),取材部位为非曝光部位正常皮肤。先用无创性皮肤生理功能测试仪检测角质层含水量、皮脂含量及经表皮水分流失(TEWL);再用RT-PCR的方法分别检测皮肤中AQP3 mRNA的表达量。结果:寻常型银屑病组角质层含水量、皮脂含量均较正常对照组降低(P<0.05),经表皮水分流失较正常对照组增加(P<0.05)。寻常型银屑病组AQP3 mRNA的表达量为(0.154±0.091),正常对照组为(0.401±0.121),寻常型银屑病组明显低于正常对照组(P<0.05)。结论:AQP3表达下降可能是银屑病皮损干燥、皮肤屏障破坏的原因之一。Objective： To observe the expression of AQP3 mRNA in psoriasis vulgaris,and to discuss its function. Methods： All 18 cases of unexposed skin lesions of psoriasis vulgaris,and 18 cases of normal unexposed skin were collected. The value of sebum content,trans-epidermal water loss（ TEWL） and water content of stratum corneum were detected,and the expression of AQP3 mRNA of every case was detected by using RT-PCR. Results： The water content and sebum content in the stratum corneum of psoriasis vulgaris were lower than those in the normal control group（ P 〈0. 05）,and the TEWL was higher than that in the normal control group（ P〈 0. 05）. The expression of AQP3 mRNA in psoriasis vulgaris is（ 0. 154 ± 0. 091）,and the expression of normal control group is（ 0. 401 ± 0. 121）. AQP3 mRNA in psoriasis vulgaris was markedly lower than the normal control group（ P 〈0. 05）. Conclusion： The decrease of AQP3 expression may be one of the causes of dry lesion and skin barrier damage in psoriasis.

关 键 词：水通道蛋白3 寻常型银屑病 皮肤屏障 

分 类 号：R556[医药卫生—血液循环系统疾病]