不同分子分型乳腺癌超声征象的研究  

Study on the ultrasound findings with different molecular subtypes of breast cancer

作　　者：吴翠怡 冯宁娜[2] 邓敏君[2] 陈伟萍[2] 吴佳偿 WU Cui-yi;FENG Ning-na;DENG Mm-jun;CHEN Wei-ping;WU Jia-chang(the Fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510195, China;Department of Ultrasound, Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510195, China)

机构地区：[1]广州中医药大学第五临床医学院,广州510195 [2]广东省第二中医院超声科,广州510195

出　　处：《中国医学前沿杂志（电子版）》2018年第3期89-93,共5页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的分析不同分子分型乳腺癌患者的彩色多普勒超声征象,探讨其超声图像特点。方法回顾性分析本院2015年3月至2017年9月收治的100例病理确诊的乳腺癌患者的病历资料,根据免疫组织化学法检测的雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)、人表皮生长因子受体2(human epidermalgrowth factor receptor-2,HER-2)及Ki67结果,分为Luminal A型、Luminal B型、HER-2过表达型及三阴型乳腺癌,所有患者均于术前行彩超检查。结果不同分子分型乳腺癌患者超声检查所示的病灶直径、边缘、内部钙化、异常淋巴结及血流信号之间对比差异均具有显著性(P<0.05),但形态、后方特征及阻力指数(resistance index,RI)对比均无显著性差异(P>0.05)。Luminal A型乳腺癌病理类型与其他分子亚型比较均具有显著差异(P<0.05)。Luminal A型乳腺癌以导管原位癌为主,而Luminal B型、HER-2过表达型及三阴型乳腺癌以浸润性导管癌为主。结论不同分子分型的乳腺癌彩色多普勒超声征象具有一定差异,这有助于临床医师更好地判断乳腺癌的分子分型,达到早期诊治的目的。Objective To investigate the color Doppler ultrasound features with different molecular subtypes of breast cancer, and explore the characteristics of ultrasonic images. Method From March 2015 to September 2017, the medical records of 100 patients with breast cancer confirmed by pathology in our hospital were retrospectively analyzed, according to the results of estrogen receptor（ER）, progesterone receptor（PR）, human epidermal growth factor receptor-2（HER-2） and Ki67 detected by immunohistochemical method, they were divided into Luminal A subtype, Luminal B subtype, HER-2 over-expressing subtype and triple-negative breast cancer, and all the patients were detected with color Doppler ultrasound before surgery. Result There were significant differences in the lesion diameter, margin, internal calcification, abnormal lymph node and blood flow signal in different molecular types of breast cancer patients（P〈0.05）, but there were no significant differences in morphology, rear features and resistance index（RI）（P〈0.05）. The pathological types of Luminal A breast cancer were significantly different from those of other molecular subtypes（P〈0.05）. Luminal A subtype was mainly ductal carcinoma in sutu, while Luminal B, HER-2 amplified and triple negative subtype were maily invasive ductal cancinoma. Conclusion Different molecular subtypes of breast cancer have certain different color Doppler ultrasound features, which helps clinicians better predict the molecular subtypes of breast cancer and achieve the goals of early diagnosis and treatment.

关 键 词：乳腺癌 分子分型 超声征象 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.9[医药卫生—诊断学]