乳腺癌超声声像图表现与CerbB-2、ER、PR的相关性分析  

Correlation analysis between ultrasonography of breast cancer and the expression of Cerb B-2, ER and PR in patients with breast cancer

作　　者：张雨[1] 巴妍.谢开 马亚凌 娜迪热.特列吾汗 ZHANG Yu;Bayan·Xiekai;MA Ya-ling;NadiraoTelewhan(Health Management Center, the First Affiliated Hospital of Xinj iang Medical University, Urumqi 830000, China;Depamnent of Ultrasound, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China)

机构地区：[1]新疆医科大学第一附属医院健康管理中心,乌鲁木齐830000 [2]新疆医科大学第一附属医院超声科,乌鲁木齐830000

出　　处：《中国医学前沿杂志（电子版）》2018年第3期94-97,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：国家自然科学基金(81360592)

摘　　要：目的分析超声检查下乳腺癌病灶直径、能量多普勒成像(power Doppler imaging,PDI)分级及淋巴结转移情况与患者原癌基因Cerb B-2、雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)的相关性。方法选择2014年11月至2016年11月于本院行超声检查并接受治疗的90例乳腺癌患者为研究对象,对患者肿瘤标本行免疫组织化学处理,分析超声检查下乳腺癌的病灶直径、PDI分级及淋巴结转移情况与Cerb B-2、ER、PR的相关性。结果90例患者中,Cerb B-2阳性率为35.56%,ER阳性率为40%,PR阳性率为33.33%。Cerb B-2、ER及FR的阳性表达与临床分期和肿瘤病灶直径无明显相关性(P>0.05)。ER阳性率与淋巴结转移呈明显的正相关(P=0.004,r=0.972),PDI分级0~Ⅰ级患者占比明显高于Ⅱ~Ⅲ级患者(P=0.000,χ2=14.24);PR阳性率与淋巴结转移无明显相关性(P>0.05);Cerb B-2阳性率与淋巴结转移呈明显的正相关(P=0.025,r=0.963),PDI分级Ⅱ~Ⅲ级患者占比明显高于0~Ⅰ级患者(P=0.000,χ2=13.33)。结论超声对乳腺癌淋巴结转移及PDI分级的诊断与Cerb B-2、ER及PR具有相关性,可为乳腺癌诊断和治疗提供参考依据。Objective To analyze the relationship between the size of breast cancer, power Doppler imaging（PDI） grade, lymph node metastasis and oncogene Cerb B-2, estrogen receptor（ER） and progesterone receptor（PR）. Method A total of 90 cases with breast cancer in our hospital from November 2014 to November 2016 were selected as research objects, the patients＇ tumor specimens were treated with immunohistochemical, explore the relationship between the size of breast cancer, PDI grade, lymph node metastasis and oncogene Cerb B-2, ER and PR. Result Among 90 cases, the positive rate of Cerb B-2 was 35.56%, the positive rate of ER was 40% and the positive rate of PR was 33.33%. There were no significant correlation between the positive expression and clinical stage of Cerb B-2, ER and FR and the size of tumor（P〈0.05）. The positive rate of ER is positively correlated with lymph node metastasis（P = 0.004, r = 0.972）, the proportion of patients with 0 ~Ⅰ PDI grade was significantly higher than those of Ⅱ~Ⅲ PDI grade（P = 0.000, χ2= 14.24）; there were no significant correlation between the positive expression of PR and lymph node metastasis. The positive rate of Cerb B-2 is positively correlated with lymph node metastasis（P = 0.025, r = 0.963）. The proportion of patients with Ⅱ~Ⅲ PDI grade was significantly higher than those of 0 ~Ⅰ PDI grade（P = 0.000, χ2= 13.33）. Conclusion The diagnosis of lymph node metastasis and PDI grade in breast cancer are associated with Cerb B-2, ER and PR, which can be helpful for the diagnosis and treatment of breast cancer.

关 键 词：乳腺癌 原癌基因 雌激素受体 孕激素受体 超声诊断 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.9[医药卫生—诊断学]