丹参注射液联合阿司匹林对急性脑梗死患者血清炎性因子水平的影响研究  

Effect of salvia miltiorrhiza injection combined with aspirin on serum inflammatory factors in patients with acute cerebral infarction

作　　者：李佳佳[1] 康玲伶[1] 马征[1] 赵亮[1] LI Jia-jia;KANG Ling-ling;MA Zheng;ZHAO Liang(Department of Neurology,Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei, Chin)

机构地区：[1]河北省承德医学院附属医院神经内科,河北承德067000

出　　处：《川北医学院学报》2018年第2期173-176,共4页Journal of North Sichuan Medical College

基　　金：河北省科技计划项目(15277752D)

摘　　要：目的:探讨丹参注射液联合阿司匹林对急性脑梗死患者血清炎性因子水平的影响研究。方法:360例急性缺血性脑梗死患者,数表法随机分为对照组和研究组,每组各180例。两组患者均给予常规治疗。对照组给予阿司匹林肠溶片,口服100 mg/次,1次/d;研究组在给予阿司匹林肠溶片的基础上再给予丹参注射液静脉滴注,1次/d,每两周为1个疗程。两组均治疗两周。治疗结束后,比较两组患者临床疗效、血液流变学指标、血浆同型半胱氨酸(Hcy)、内皮素(ET)、神经元特异性烯醇化酶(NSE)、超氧化物歧化酶(SOD)变化含量、血清白介素-6(IL-6)和肿瘤坏死因子(TNF-α)水平。结果:治疗后,与对照组相比,研究组临床总有效率显著升高(P<0.05)。治疗两周时,与入院时相比,研究组血浆Hcy、ET和NSE水平明显降低(P<0.05),而血浆SOD活性明显升高(P<0.05);与对照组比较,研究组血浆Hcy、ET、NSE及SOD水平降低更明显,血浆SOD活性增加更显著。治疗两周,与入院时和对照组相比,研究组全血浆黏度、全血黏度、红细胞比积、红细胞聚集指数降低更明显(P<0.05)。治疗两周与入院时相比,两组血清IL-6、TNF-α水平均明显降低(P<0.05);与对照组相比,研究组血清中IL-6、TNF-α水平均明显较低(P<0.05)。结论:在急性脑梗死患者中,应用丹参注射液联合阿司匹林肠溶片可以明显改善临床症状,下调炎症因子IL-6、TNF-α水平,血液流变学指标明显改善,适宜临床应用推广。Objective： To investigate the effect of salvia miltiorrhiza injection combined with aspirin on serum inflammatory cytokines in patients with acute cerebral infarction. Methods： A total of 360 patients of acute ischemic cerebral infarction were divided into two groups randomly,180 in each group. The control group was treated routinely with oral aspirin enteric-coated tablets,100 mg/times,once a day. The research group was treated routinely with salvia miltiorrhiza by intravenous drop on the basis of oral aspirin enteric-coated tablets,once a day,two weeks as one of treatment courses. Both groups were treated for two weeks. After two weeks,the clinical effect,hemorheology indexes,plasma homocysteine（ Hcy）,Endothelin（ ET）,neuron-specific enolase（ NSE）,superoxide dismutase（ SOD） level,interleukin-6（ IL-6） and Tumor necrosis factor（ TNF-α） levels were observed. Results： After two weeks,compared with the control group,the clinical effect of the research group was increased significantly（ P〈0. 05）. Compared with the hospital,the levels of plasma Hcy,ET and NSE in the study group were significantly decreased（ P〈0. 05）,while the activity of plasma SOD was significantly increased（ P〈0. 05）. Compared with the control group,the levels of plasma Hcy,ET,NSE and SOD were decreased,and the activity of plasma SOD increased more significantly. Compared with the control group,the whole blood viscosity,serum viscosity,hematoerit,erythrocyte aggregation index in the research group were decreased significantly after treatment（ P〈0. 05）. The levels of IL-6,TNF-α in the both groups were decreased significantly（ P〈0. 05）. Compared with the control group,the level of IL-6,TNF-α in the research group were decreased significantly（ P〈0. 05）. Conclusion： The combined with salvia injection and aspirin enteric-coated tablets can improve clinical symptoms and hemorheology indexes and decrease the levels of IL-6,TNF-α in the acutecerebral infarction patients,which is suitable

关 键 词：脑梗死 炎性因子 丹参注射液 阿司匹林 急性 

分 类 号：R453[医药卫生—治疗学]