Large-area gold nanohole arrays fabricated by one-step method for surface plasmon resonance biochemical sensing  

作　　者：Huijie Qi Lihong Niu Jie Zhang Jian Chen Shujie Wang Jingjing Yang Siyi Guo Tom Lawson Bingyang Shi Chunpeng Song 

机构地区：[1]State Key Laboratory of Cotton Biology, Key Laboratory of Plant Stress Biology, School of Life Sciences,Henan University [2]Key Laboratory for Special Functional Materials of Ministry of Education, Henan University [3]International Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University [4]ARC Centre of Nanoscale Biophotonics, Macquarie University

出　　处：《Science China(Life Sciences)》2018年第4期476-482,共7页中国科学（生命科学英文版）

基　　金：financially supported by the National Natural Science Foundation of China (31430061, 61401149, and U1604177);Ministry of Agriculture of China (2016ZX08009-003);the Program of China’s 1000-talents Plan

摘　　要：Surface plasmon resonance(SPR) nanosensors based on metallic nanohole arrays have been widely reported to detect binding interactions in biological specimens. A simple and effective method for constructing nanoscale arrays is essential for the development of SPR nanosensors. In this work, we report a one-step method to fabricate nanohole arrays by thermal nanoimprinting in the matrix of IPS(Intermediate Polymer Stamp). No additional etching process or supporting substrate is required. The preparation process is simple, time-saving and compatible for roll-to-roll process, potentially allowing mass production. Moreover, the nanohole arrays were integrated into detection platform as SPR sensors to investigate different types of biological binding interactions. The results demonstrate that our one-step method can be used to efficiently fabricate large-area and uniform nanohole arrays for biochemical sensing.Surface plasmon resonance （SPR） nanosensors based on metallic nanohole arrays have been widely reported to detect binding interactions in biological specimens. A simple and effective method for constructing nanoscale arrays is essential for the development of SPR nanosensors. In this work, we report a one-step method to fabricate nanohole arrays by thermal na- noimprinting in the matrix of IPS （Intermediate Polymer Stamp）. No additional etching process or supporting substrate is required. The preparation process is simple, time-saving and compatible for roll-to-roll process, potentially allowing mass production. Moreover, the nanohole arrays were integrated into detection platform as SPR sensors to investigate different types of biological binding interactions. The results demonstrate that our one-step method can be used to efficiently fabricate large-area and uniform nanohole arrays for biochemical sensing.

关 键 词：gold nanohole arrays one-step method NANOIMPRINTING NANOSENSOR biomolccular binding 

分 类 号：Q6-33[生物学—生物物理学] TP212[自动化与计算机技术—检测技术与自动化装置]