Highly enantioselective cyclopropanation of trisubstituted olefins  

作　　者：Jun Li Long Zheng Hao Chen Lijia Wang Xiu-Li Sun Jun Zhu Yong Tang 

机构地区：[1]The State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200032, China [2]Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China

出　　处：《Science China Chemistry》2018年第5期526-530,共5页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21432011,21772224);Key Research Program of Frontier Sciences of Chinese Academy of Sciences(QYZDY-SSWSLH016);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB20000000);the Youth Innovation Promotion Association CAS(2017301);the National Basic Research Program of China(2015CB856600)

摘　　要：A highly efficient asymmetric cyclopropanation of trisubstituted olefins with methyl diazoacetate has been developed in terms of an elaborate modified chiral bisoxazoline/copper complex as a catalyst. A broad scope of substrates is compatible with this catalyst system, including various trisubstituted olefins bearing different aryl-, fused aryl-and alkyl-substituents, providing an easy access to optically active 1,1-dimethyl cyclopropanes in good yields with excellent diastereo-and enantio-selectivity.A highly efficient asymmetric cyclopropanation of trisubstituted olefins with methyl diazoacetate has been developed in terms of an elaborate modified chiral bisoxazoline/copper complex as a catalyst. A broad scope of substrates is compatible with this catalyst system, including various trisubstituted olefins bearing different aryl-, fused aryl-and alkyl-substituents, providing an easy access to optically active 1,1-dimethyl cyclopropanes in good yields with excellent diastereo-and enantio-selectivity.

关 键 词：cyclopropanation enantioselective bisoxazoline copper diazoacetate 

分 类 号：O621.251[理学—有机化学]