GMP-quadruplex-based hydrogels stabilized by lanthanide ions  

作　　者：Jin Zhang Xiaoyang Li Xiuping Sun Aixin Song Yebang Tan Jingcheng Hao 

机构地区：[1]Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Shandong University

出　　处：《Science China Chemistry》2018年第5期604-612,共9页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21573134,21420102006)

摘　　要：This work describes the gelation behaviors and properties of a biological molecule, guanosine 5′-monophosphate disodium salt(GMP), in the presence of trivalent lanthanide ions. Hydrogels composed of GMP-quadruplexes were prepared by adjusting p H,through which the protonation of phosphate group was controlled to tune the interactions between lanthanide ions and GMP.Within the p H region of 2–6, the electrostatic interaction between lanthanide ions and phosphate group is hindered and the cation-dipole interaction acts as the main driving force for the formation of G-quadruplexes. All the hydrogels were found consisting of three-dimensional network of the intertwining one-dimensional nanofibers formed by the stacking G-quartets induced by lanthanide ions. A significant fluorescence enhancement of thioflavin T(Th T), a fluorescent molecule, was found to be triggered by the G-quadruplex structures, for which the rotation of chromophoric groups on Th T molecules were prohibited due to the implant into the G-quadruplex structures.This work describes the gelation behaviors and properties of a biological molecule, guanosine 5′-monophosphate disodium salt（GMP）, in the presence of trivalent lanthanide ions. Hydrogels composed of GMP-quadruplexes were prepared by adjusting p H,through which the protonation of phosphate group was controlled to tune the interactions between lanthanide ions and GMP.Within the p H region of 2–6, the electrostatic interaction between lanthanide ions and phosphate group is hindered and the cation-dipole interaction acts as the main driving force for the formation of G-quadruplexes. All the hydrogels were found consisting of three-dimensional network of the intertwining one-dimensional nanofibers formed by the stacking G-quartets induced by lanthanide ions. A significant fluorescence enhancement of thioflavin T（Th T）, a fluorescent molecule, was found to be triggered by the G-quadruplex structures, for which the rotation of chromophoric groups on Th T molecules were prohibited due to the implant into the G-quadruplex structures.

关 键 词：G-quadruplex hydrogel hydrogen bonding electrostatic interaction ion-dipole interaction fluorescence enhancement 

分 类 号：O648.17[理学—物理化学]