烟酰胺单核苷酸的研究及应用进展  

Progress on research and application of nicotinamide mononucleotides

作　　者：赵娟 张健[1] 余志坚 曹永强 陈超 杨贞耐[1,2] ZHAO Juan;ZHANG Jian;YU Zhi-jian;CAO Yong-qiang;CHEN Chao;YANG Zhen-nai(Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Technology ＆ Business University, Beijing 100048;Dongjun Dairy （Yucheng） Co., Ltd., Yucheng 251200)

机构地区：[1]北京食品营养与人类健康高精尖创新中心、食品添加剂与配料北京高校工程研究中心,北京工商大学,北京100048 [2]东君乳业(禹城)有限公司,禹城251200

出　　处：《食品科技》2018年第4期257-262,共6页Food Science and Technology

基　　金：国家自然科学基金面上项目(31371804); 北京工商大学横向课题(2017065)

摘　　要：烟酰胺单核苷酸(Nicotinamide mononucleotide,NMN)是哺乳动物体内烟酰胺腺嘌呤二核苷酸(Nicotinamide adenine dinucleotide,NAD+)补救合成途径的中间体。近年研究发现,人为补充NMN能够修复脑损伤、改善胰岛功能、保护心脏免于缺血再灌注损伤、修复脑线粒体呼吸缺陷,对老年退行性疾病、视网膜退行性疾病、2型糖尿病、脑出血等均具有一定治疗作用。文章系统综述了NMN的基本性质、来源、生物活性及其应用前景,旨在为NMN在食品、保健品和药品方面的开发和应用提供参考。Nicotinamide mononucleotide（NMN） is an intermediate in salvage pathway of nicotinamide adenine dinucleotide（NAD＋） in mammals. Recent studies show that supplement of NMN can repair brain damage, improve islet function, protect the heart from ischemia-reperfusion injury and repair brain mitochondrial respiratory defects. Furthermore, NMN has a certain therapeutic effect on degenerative diseases, retina degenerative diseases, type 2 diabetes, cerebral hemorrhage, etc. This paper systematically reviews the basic nature, source, biological activity and application prospect of NMN, aiming to provide references for the development and application of NMN in food, health care products and drugs.

关 键 词：烟酰胺单核苷酸 生物活性 应用 

分 类 号：TS218.1[轻工技术与工程—粮食、油脂及植物蛋白工程]