纳米磁性药物载体的制备及其物理性能  

Preparation of magnetic nanoparticle - albumin - 2, 2＇ - dipyridyl and analysis of their physicalproperty

作　　者：桂铮 于耀宇[1] 汪子文[1] 卢学刚[2] 郭栋[1] 朱明[1] 李臻[1] 水少峰[1] 韩新巍[1] Gui Zheng;Yu Yaoyu;Wang Ziwen;Lu Xuegang;Guo Dong;Zhu Ming;Li Zhen;Shui Shaofeng;Han Xinwei(Department of Interventional Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 4500S2, Chin;Department of Material Physics, School of Science, Xi＇an Jiaotong University, Xi＇an 710049, Chin)

机构地区：[1]郑州大学第一附属医院介入科,450052 [2]西安交通大学理学院材料物理学系,710049

出　　处：《中华实验外科杂志》2018年第4期687-688,共2页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金（81171116）

摘　　要：目的探讨纳米磁性药物载体2，2’-联吡啶（2，2’-dipyridyl）磁性白蛋白纳米粒（MNA-DPD）的制备工艺并分析其物理性能。 方法应用化学反应制备纳米级的磁流体（Fe3O4），用热处理法将人血浆蛋白质和2，2’-联吡啶分散在磁流体中，在高速超声搅拌下加热，使蛋白质稳定，得到蛋白质包覆的生物相容性MNA-DPD。进一步分析MNA-DPD磁响应性、磁特性、靶向性和分散性。 结果成功制备稳定的纳米级的MNA-DPD，其平均粒径（D）＝131.3 nm。物理性能分析结果显示，制备出的MNA-DPD具有良好的磁响应性、磁特性、靶向性、分散性。 结论用热处理法可以制备纳米级、具有良好磁响应性、磁特性、靶向性、分散性的MNA-DPD。ObjectiveTo explore the method of preparing the magnetic nanoparticle- albumin-2, 2’-dipyridyl （MNA-DPD） and to analyze their physical property. MethodsPrepare the MNA-DPD using heat treatment method： The human plasma albumin and 2, 2’-dipyridyl were dispersed in the magnetic nanoparticles （Fe3O4）. Steady the protein by heat treatment and stiring with ultrasound. Then biocompatible MNA-DPD was acquired. Analyzed the magnetic responsibility, magnetic character, targeting and dispersibility of MNA-DPD. ResultsThe MNA-DPD whose mean diameter was 131.3 nm were successfully prepared. The MNA-DPD had good magnetic responsibility, magnetic character, targeting and dispersibility. ConclusionThe MNA-DPD can be prepared by heat treatment method. The MNA-DPD was of nanoscale and had good magnetic responsibility, magnetic character, targeting and dispersibility, and ti may provide new methods for the treatment of cerebrovascular disease.

关 键 词：磁性纳米颗粒 药物载体 制备 方法 物理性能 

分 类 号：R943[医药卫生—药剂学] R96[医药卫生—药学]