富勒烯及其衍生物应用于骨科领域的研究进展  

Research progress of fullerene and its derivatives applied in orthopedic field

作　　者：马宏道 刘宏建[1] 杨新林[2] 金莉 崔全军[2] 尚国伟[1] Ma Hongdao;Liu Hongjian;Yang Xinlin;Jin Li;Cui Quanjun;Shang Guowei(Department of Orthopedics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Chin;Department of Orthopedic Surgery, University of Virginia School of Medicine, Charlottesville 22903, United States)

机构地区：[1]郑州大学第一附属医院骨科,450052 [2]美国弗吉尼亚大学医院骨科实验室,夏洛茨维尔22903

出　　处：《中华实验外科杂志》2018年第4期788-790,共3页Chinese Journal of Experimental Surgery

摘　　要：富勒烯（Fullerene）及其衍生物自被发现以来，以其独特的结构和无可比拟的理化性质，在生物医学研究中得到了广泛应用。富勒烯的生物学特性主要体现在对自由基的吸附清除作用和强抗氧化性，被赞誉为＂自由基海绵＂。诸多研究结果表明，活性氧自由基（ROS）调节了细胞增殖、分化、凋亡等细胞功能。在骨科领域，ROS则与细胞成骨分化、骨性关节炎关节软骨退变、类风湿关节炎炎症的介导、骨坏死、骨质疏松、椎间盘退变等疾病发生机制密切相关。富勒烯及其衍生物通过影响ROS水平，间接达到不同的生物学目的。现从生理和疾病产生的机制入手，就富勒烯C60及其衍生物在骨组织干细胞工程、非化脓性关节炎、骨质破坏、椎间盘退变及其诱发腰痛等方面的研究进展进行综述。Since fullerenes and its representative were discovered, they have been widely used in biomedical research with their unique structure and incomparable physical and chemical properties. The biological characteristics of fullerenes are mainly reflected in the adsorption and removal of free radicals and strong anti-oxidation, which are praised as ＂free radical sponges＂ . Many studies have shown that reactive oxygen species （ROS）, as the main reason for oxidative stress in the body, regulates cell proliferation, differentiation, apoptosis and other cellular functions. In the field of orthopaedics, ROS is closely associated with physiological changes and mechanisms of disease progression such as cell osteogenic differentiation, osteoarthritis, rheumatoid arthritis, osteonecrosis, osteoporosis, and intervertebral disc degeneration. Fullerenes and their derivatives are used to influence ROS levels to regulate signaling pathways of inflammatory cytokines and cell osteogenesis or adipogenesis, thereby, achieving different biological objectives. In this paper, through literature review, we summarize the research progress about fullerene C60 and its derivatives in bone tissue engineering stem cells, nonsuppurative arthritis, bone destruction, intervertebral disc degeneration and induced low back pain from the physical and disease generation mechanism, and hope to provide new ideas for the treatment of these diseases and new potential avenues for other orthopedic diseases.

关 键 词：富勒烯 抗氧化剂 活性氧 骨科应用 

分 类 号：R68[医药卫生—骨科学]