海藻酸钠-g-聚丙烯酰胺/氧化石墨烯复合水凝胶的制备及控释行为  

Preparation and Controlled Release Behavior of Sodium Alginate-g-Polyacrylamide/Graphene Oxide Composite Hydrogel

作　　者：邵宇 吴称意[2,1] 程超 李聪 张旭 郑寅 吴少尉 Yu Shao;Chengyi Wu;Chao Cheng;Cong Li;Xu Zhang;Yin Zheng;Shaowei Wu(Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province, Enshi 445000, China;College of Chemistry and Environmental Engineering, Hubei University of Nationalities, Enshi 445000, China)

机构地区：[1]湖北民族学院化学与环境工程学院,湖北恩施445000 [2]生物资源保护与利用湖北省重点实验室,湖北恩施445000

出　　处：《高分子材料科学与工程》2018年第4期104-109,共6页Polymer Materials Science & Engineering

基　　金：湖北省教育厅科学研究计划(Q20171905)

摘　　要：以海藻酸、丙烯酰胺为单体,氧化石墨烯为原料制备了海藻酸钠-g-聚丙烯酰胺/氧化石墨烯(NaAlg-g-PAAm/GO)复合水凝胶,采用傅里叶变换红外光谱和扫描电镜对其结构和形貌进行了表征;当GO的质量分数从0.6%增至3.2%时,溶胀率从37%减至21%;阳离子对水凝胶的溶胀性的影响能力是Fe3+>Ca2+>K+;以5-氟尿嘧啶(5-FU)为抗癌药物模型,模拟胃腔和小肠的环境,研究了在pH=1.2和pH=7.4的缓冲溶液中复合水凝胶的控制释放行为,实验结果表明水凝胶在pH=7.4的缓冲溶液中的累积释放率明显高于在pH=1.2的溶液中的累积释放率,所以该类水凝胶有望成为靶向药物释放的载体。Sodium alginate-g-polyacrylamide/ graphene oxide （NaAlg-g-PAAm/GO） composite hydrogel was prepared by solution polymerization with alginate, acrylamide as monomer, graphene oxide as raw material. The structure and morphology of composite hydrogel were characterized by Fourier transform infrared spectroscopy （FT- IR） and scanning electron microscopy （SEM）. The mass fraction of GO increases from 0.6% to 3.2% and the swelling ratio （SR） decreases from 37% to 21%：The effect of cations on the swelling of hydrogels is as follow： Fe3＋ 〉Ca2＋ 〉K＋ . In order to imitate the simulated gastric cavity and intestinal environment, using 5-fluorouracil （5-FU） as model for anticancer drug, the controlled release behavior of composite hydrogel was investigated in buffer solution of pH = 1.2 and pH = 7.4. The experimental results show that the cumulative release （84 % ） of hydrogel in pH= 7.4 buffer solution is significantly higher than that in the solution of pH= 1.2, so this kind of hydrogel is expected to become carrier of targeted drug release.

关 键 词：复合水凝胶 控制释放 氧化石墨烯 溶胀 

分 类 号：O648.17[理学—物理化学]