慢性阻塞性肺疾病急性加重患者免疫球蛋白的表达及临床意义  

The expression and clinical value of immune globulin in patients with AECOPD

作　　者：武元星[1] 黄立学 朱光发[1] Wu Yuan - xing;Huang Li -xue;Zhu Guang -fa.(Department of Pulmonary and Critical Care Medicine, Bering Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China)

机构地区：[1]首都医科大学附属北京安贞医院呼吸与危重症医学科-北京市心肺血管疾病研究所,北京100029

出　　处：《中国急救医学》2018年第4期294-297,共4页Chinese Journal of Critical Care Medicine

基　　金：首都卫生发展科研专项基金（首发2016-2-1052）

摘　　要：目的 研究慢性阻塞性肺疾病急性加重（COPD）患者免疫球蛋白表达特点及临床意义。方法 观察2016-01-2017-01在首都医科大学附属北京安贞医院呼吸与危重症医学科就诊的慢性阻塞性肺疾病急性加重（AECOPD）患者，符合入选和排除标准患者共122例，通过急性加重危险评估从低到高危分为A、B、C、D四组，A组22例，B组39例，C组35例，D组26例，同时纪录同期健康体检中心体检者30例作为健康对照组，测定免疫球蛋白A（IgA）、免疫球蛋白M（IgM）、免疫球蛋白G（IgG）、免疫球蛋白E（IgE）和白蛋白（ALB）。结果〓〖HTSS〗B组和C组IgE均明显高于健康对照组（P值分别为0.007、＜0.001）；A、B、D组IgA均明显低于健康组（P值分别为＜0.001、0.005、0.036）；A、B、D组IgG均明显低于健康组（P值分别为0.004、＜0.001、0.001）；A组和B组IgM均明显低于健康组（P值分别为0.004、＜0.001）；各组ALB均明显低于健康组（P＜0.001）。结论 COPD患者存在体液免疫功能障碍，同时也存在IgE的升高，增强免疫的治疗和根据IgE水平酌情使用激素吸入治疗可能是COPD免疫防治的方法之一。Objective To investigate the expression and clinical value of immune globulin in patients with AECOPD. Methods One hundred and twenty - two COPD patients were divided into four groups aceoding to the evaluation of acute exacerbation from Jan 2016 to Jan 2017. Twenty - two patients were in A group, 39 patients were in B group, 35 patients were in C group, 26 patients were in D group and and another 30 healthy subjects as the control group. IgA, IgM, IgG, IgE and ALB were detected. Results There were significant differences in IgA, IgG, IgM and ALB among the five groups （P 〈 O. 05）. Comparison of lgE in group B and C and was higher than that in health group, respectively P values 0.007, 〈 0. 001; comparison of IgA in the group A, B and D was lower than that in health group, respectively P values 〈 0. 001, 0. 005, 0. 036 ; comparison of IgG in the group A, B and D was lower than that in health group, respectively P values 0.004, 〈 0. 001, 0. 001 ;comparison of IgM in the group A and B was lower than that in health group, respectively P values 0. 004, 〈0.001; comparison of ALB in A, B, C and D group were all lower than that in health group, P 〈 0. 001. Conclusion Humoral immune dysfunction exists in COPD patients, at the same time, there is an increase in IgE, the treatment of immunotherapy and the use of hormone inhalation in accordance with IgE levels may be one of the ways of preventing and treating COPD.

关 键 词：慢性阻塞性肺疾病(COPD) 急性加重 免疫球蛋白(IgE) 免疫 

分 类 号：R563[医药卫生—呼吸系统]