厚朴排气合剂在急性有机磷农药中毒患者抢救中的应用效果  

Application effect of Magnolia officinalis exhaust mixture in the rescue of acute organophosphorus pesticide poisoning

作　　者：郭文平[1] 高辉[2] 陈丽霞[2] 赵麦良[2] 杨宇[2] 张圣[2] 张延成 窦志霞 Guo Wen -ping;Gao Hui;Chen Li - xia;Zhao Mai - liang;Yang Yu;Zhang Sheng;Zhang Yan - wei;Dou Zhi - xia(Department of Rehabilitation Medicine, Xingtai People＇s Hospital, Xingtai 054001, China)

机构地区：[1]邢台市人民医院中医康复科,河北邢台054001 [2]邢台市人民医院急救部国,河北邢台054001 [3]河北省眼科医院麻醉科,河北邢台054001

出　　处：《中国急救医学》2018年第4期310-313,共4页Chinese Journal of Critical Care Medicine

基　　金：邢台市科技支撑计划（2015ZC082）

摘　　要：目的 探讨厚朴排气合剂在急性有机磷农药中毒（AOPP）患者抢救中的应用效果。 方法 选择2015-10～2017-06于急诊首诊的口服有机磷农药中毒患者102例，依照单纯随机抽样分组原则分为厚朴组和对照组各51例。两组均按AOPP诊疗规范给予常规方案治疗，洗胃后应用甘露醇导泻和药用炭片吸附毒物，厚朴组于导泻剂后再给予厚朴排气合剂口服或胃管内注入（50 mL/次），间隔6 h后再次给予。观察两组患者首次排便时间、24 h内排便次数和排出黑便时间，两组患者治疗用阿托品使用总量、住院时间及临床治疗效果，并观察药物反应情况。结果 厚朴组首次排便时间、排出黑便时间短于对照组（h：10.1±4.6比12.1±5.4，13.3±4.1比15.9±6.0，均P〈0.05），24 h排便次数多于对照组（次：3.3±0.3比2.9±0.4，P〈0.05）；两组治疗使用阿托品总量比较，厚朴组少于对照组（mg：67.1±21.5比80.8±22.7，P〈0.05）；治疗终结时，厚朴组平均住院时间短于对照组（d：12.0±3.1比13.7±3.9，P〈0.05），治愈率比较变化不明显［90.2%（46/51）比82.3%（42/51），P〉0.05〕，未发现药物相关不良反应。结论 口服有机磷农药中毒的患者应用厚朴排气合剂，可促进胃肠蠕动，促使胃肠道内毒物尽快排出，增强导泻效果，有利于提高临床疗效。Objective To investigate the effect of Magnolia officinalis exhaust mixture in the rescue of organophosphorus pesticide poisoning patients. Methods 102 oral organophosphorus pesticide poisoning patients were chosen from October 2015 to June 2017 in the emergency department. Patients were divided into two groups： the magnolia officinalis group and control group with 51 cases in each group. All patients were given comprehensive treatment accordance with the organic phosphorus pesticide poisoning treatment. In the Magnolia group laxative after houpupaiqi mixture orally or injected into stomach, 50 mL/time, after an interval of 6 h. The first defecation time, the frequency of defecation and the time of excretion of 24 h in the two groups were observed. The total amount of atropine used in the two groups, the length of stay and the effect of clinical treatment were observed, and the reaction of the drug was observed. Results The first defecation time, black stool time in Magnolia officinalis group were shorter than those in the control group （ h： 10.1 ± 4.6 vs. 12.1 ± 5.4, 13.3 ± 4.1 vs. 15.9 ± 6. 0, P 〈 0. 05 ）, 24 h defecation times in Magnolia officinalis group was more than that in the control group （ defecation time ： 3.3 ± 0. 3 vs. 2.9 ±0. 4, P 〈 0. 05 ） ; the total dose of atropine in Magnolia officinalis group was lower than that in the control group （rag： 67. 1 ± 21.5 vs. 80.8 ± 22.7, P〈 0. 05 ） ; at the end of treatment, the average hospitalization time in Magnolia group was shorter than that in the control group （d： 12.0±3.1 vs. 13.7 ±3.9, P〈0.05）, but the cure rate did not change significantly [90.2% （46/51） vs. 82.3% （42/51）, P 〉 O. 05]; there were no drug related adverse reactions occurred during the treatment. Conclusion For the oral organophosphorus pesticide poisoning patients, Magnolia officinalis exhaust mixture can promote gastrointestinal peristalsis, promote gastrointestinal poison discharged as soon as possible, enhance the catharsis effect,

关 键 词：急性有机磷农药中毒(AOPP) 口服 厚朴排气合剂 导泻 

分 类 号：R595.4[医药卫生—内科学]